79989-07-4

Basic information

• Product Name: (E)-(4-bromo-but-2-enyloxy)-benzene
• Synonyms: (E)-(4-bromo-but-2-enyloxy)-benzene
• CAS NO: 79989-07-4
• Molecular Weight: 227.101
• Mol File: 79989-07-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-(4-bromo-but-2-enyloxy)-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-(4-bromo-but-2-enyloxy)-benzene(79989-07-4)
• EPA Substance Registry System: (E)-(4-bromo-but-2-enyloxy)-benzene(79989-07-4)

Safety Data

• Hazardous Substances Data: 79989-07-4(Hazardous Substances Data)

Upstream product

• 821-06-7 (E)-1,4-dibromobutene 
• 108-95-2 phenol 
• 71-43-2 benzene 
• 100-67-4 potassium phenolate 

Downstream Products

• 106139-66-6 16α-(4-phenoxy-2-butenyl)-3-<(tert-butyldimethylsilyl)oxy>estra-1,3,5(10)-trien-17β-ol 
• 186886-95-3 O-[2-(1-phenoxybut-3-enyl)]-N-methyl-N-phenylhydroxylamine 
• 106-99-0 buta-1,3-diene 
• 108-95-2 phenol 
• 186886-85-1 N-methyl-N-phenyl-N-[1-((E)-4-phenoxybut-2-enyl)]amine 
• 106139-58-6 16α-(4-phenoxy-2-butenyl)-3-<(tert-butyldimethylsilyl)oxy>estra-1,3,5(10)-trien-17-one 
• 15779-52-9 (E)-1,4-diphenoxybut-2-ene 

Relevant articles and documents

Promising fungicides from allelochemicals: Synthesis of umbelliferone derivatives and their structure–activity relationships

Umbelliferone was discovered to be an important allelochemical in our previous study, but the contribution of its activity and structure has not yet been revealed. In this study, a series of analogues were synthesized to determine the skeleton of umbelliferone and examine its fungicidal activity. Furthermore, targeted modifications were conducted with three plant parasitic fungi to examine the lead compounds. Among those tested, compounds 2f and 10 were found to show excellent antifungal activity with an inhibitory rate over 80% at 100 ug/mL. The study proves that umbelliferone can be a promising skeleton for fungicides discovery. In addition, the primary structure–activity relationship provides a good guidance for the discovery of novel fungicides based on natural products in the future.

MODIFICATION OF THE NICKL REACTION. A GENERAL SYNTHETIC APPROACH TO 2-VINYL-2,3-DIHYDROBENZOFURANS

The annelation reaction of metal phenolates 1 with 1,4-dibromo-2-butenes 2 to give 2-vinyl-2,3-dihydrobenzofuran derivatives 3 (Nickl reaction) was critically examined and markedly improved.Use of lithium phenolates, instead of sodium phenolates, as substrates and toluene, instead of methanol, as reaction medium, caused the yield of annelated compounds to rise dramatically.The relevance of this modified route to the synthesis of Euparinoid 2,3-dihydrobenzofurans and their synthetic analogues was emphasized.