8001-23-8 Usage
Description
Safflower oil, derived from the seeds of the Carthamus tinctorius plant, is a non-comedogenic carrier oil known for its hydrating properties for the skin. It is primarily composed of linoleic acid triglycerides, making it a valuable component in various applications.
Uses
Used in Skincare Industry:
Safflower oil is used as a hydrating agent for the skin due to its non-comedogenic nature and ability to provide moisture without clogging pores.
Used in Pharmaceutical Industry:
Safflower oil is used as a carrier oil for pharmaceutical applications, given its capacity to deliver active ingredients effectively and safely.
Used in Cosmetic Industry:
Safflower oil is used as an ingredient in cosmetic products for its moisturizing and nourishing properties, enhancing the skin's overall health and appearance.
Used in Paint and Varnish Industry:
Safflower oil is used as a drying oil in the USA, primarily for its ability to solidify and provide a hard, protective film when used in paint and varnish formulations.
Production Methods
Refined safflower oil is the fatty oil obtained from the seeds of
Carthamus tinctorius L. (type I) or from seeds of hybrids of
Carthamus tinctorius L. (type II) by expression and/or extraction followed by refining. Type II refined safflower oil is rich in oleic (cis-
9-octadecenoic) acid. It may contain a suitable antioxidant.
Safflower oil USP 32 is the refined fixed oil yielded by the seed of
Carthamus tinctorius Linne′ (Fam. Compositae).
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Safflower oil react with acids to liberate heat. Heat is also generated by interaction with caustic solutions. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Flammable hydrogen is generated by mixing with alkali metals and hydrides. React slowly with oxygen in the air to thicken and become rancid.
Health Hazard
Oil is essentially nontoxic. Contact with eyes can cause mild irritation.
Fire Hazard
Flash point data for Safflower oil are not available; however, Safflower oil is probably combustible.
Pharmaceutical Applications
Safflower oil is mainly used as an oleaginous vehicle in oral and
topical formulations. It is also used as a component of parenteral fat
emulsions for the preparation of parenteral nutrition solutions.
Safflower oil has been used as a vehicle in the development of an
oral dosage form containing a novel viral-specific inhibitor of the
replication of human rhinoviruses. It has also been used as a
solvent for a capsule formulation containing a new antilipemic
agent; formulations containing safflower oil were found to have the
greatest bioavailability in dogs compared with formulations
containing PEG 300 or water.
A topical lotion containing 3% safflower oil is commercially
available, and parenteral fat emulsions containing a mixture of
safflower oil 5% and soya oil 5%, or 10% and 10%, respectively,
have been administered as part of total parenteral nutrition regimes.
Safflower oil is used as a food, being consumed in the form of
soft margarine, salad oils, and cooking oils. It is also used in
cosmetics products such as soaps, lotions, creams, and hair-care
preparations.
Safety
Safflower oil is an edible oil and generally presents no significant
health hazards following eye contact, skin contact, oral ingestion, or
inhalation. Skin irritation or allergic reactions, or eye irritation may
occur. Ingestion of large doses can cause vomiting. Safflower oil
may cause diarrhea.
LD50 (mouse, IP): >50 g/kg
storage
Safflower oil thickens and becomes rancid on prolonged exposure
to air. It is also sensitive to light. Safflower oil should be preserved in
tight, light-resistant containers. Refined safflower oil should be
stored in a well-filled, airtight container, protected from light.
Parenteral fat emulsions containing safflower oil are destabilized
by electrolytes; severe droplet coalescence in the emulsion occurs
3–5 days after the addition of 10% v/v dimethyl sulfoxide, and after
10 days if 5% v/v is added. Parenteral fat emulsions are prone to
bacterial and fungal growth. Generally, fat emulsions containing
safflower oil or soybean oil show similar growth patterns, although growth of Candida albicans has been reported to be higher
in safflower oil containing fat emulsions than in other types of
emulsion.
Incompatibilities
Safflower oil is incompatible with strong oxidizing agents.
Regulatory Status
Included in the FDA Inactive Ingredients Database (topical lotion).
Included in the Canadian List of Acceptable Non-medicinal
Ingredients. Included in an intravenous fat emulsion (Liposyn II)
available in the USA. Included in a capsule formulation available in
Canada and in a non-medicinal capsule formulation previously
available in the UK. It is also a component of a Canadian enteral
nutrition preparation.
Check Digit Verification of cas no
The CAS Registry Mumber 8001-23-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 8,0,0 and 1 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 8001-23:
(6*8)+(5*0)+(4*0)+(3*1)+(2*2)+(1*3)=58
58 % 10 = 8
So 8001-23-8 is a valid CAS Registry Number.