80151-26-4

Basic information

• Product Name: 3-(2-CHLOROPHENYL)PROP-2-YN-1-OL
• Synonyms: AKOS PRN-0001;3-(2-CHLOROPHENYL)PROP-2-YN-1-OL;3-(2-Chlorophenyl)-2-propyn-1-ol
• CAS NO: 80151-26-4
• Molecular Formula: C₉H₇ClO
• Molecular Weight: 166.6
• Mol File: 80151-26-4.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 281.5 °C at 760 mmHg
• Flash Point: 124 °C
• Appearance: /
• Density: 1.26 g/cm³
• Vapor Pressure: 0.00168mmHg at 25°C
• Refractive Index: 1.601
• CAS DataBase Reference: 3-(2-CHLOROPHENYL)PROP-2-YN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-CHLOROPHENYL)PROP-2-YN-1-OL(80151-26-4)
• EPA Substance Registry System: 3-(2-CHLOROPHENYL)PROP-2-YN-1-OL(80151-26-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 80151-26-4(Hazardous Substances Data)

Usage

General Description

3-(2-Chlorophenyl)prop-2-yn-1-ol is a chemical compound with the molecular formula C9H7ClO. It is a colorless to pale yellow liquid that is commonly used in the synthesis of pharmaceuticals and agrochemicals. 3-(2-CHLOROPHENYL)PROP-2-YN-1-OL is also known for its potential anti-cancer properties and has been studied for its ability to inhibit the growth of cancer cells. Additionally, 3-(2-Chlorophenyl)prop-2-yn-1-ol is used as a reagent in organic synthesis, particularly in the preparation of alkyne-containing compounds. It is important to handle this chemical compound with care, as it can be hazardous if not used properly.

InChI:InChI=1/C9H7ClO/c10-9-6-2-1-4-8(9)5-3-7-11/h1-2,4,6,11H,7H2

Upstream product

• 615-41-8 2-iodochlorobenzene 
• 107-19-7 propargyl alcohol 
• 694-80-4 2-bromo-1-chlorobenzene 

Downstream Products

• 129425-32-7 1-(3-bromo-1-propynyl)-2-chlorobenzene 
• 501098-87-9 3-(2-chlorophenyl)propiolaldehyde 
• 869317-70-4 1-chloro-2-(3-prop-2-ynyloxyprop-1-ynyl)benzene 
• 6054-00-8 3-phenyl-2H-benzopyran 
• 148775-24-0 (2E)-3-(2-chlorophenyl)-prop-2-en-1-ol 

Relevant articles and documents

One-pot synthesis of 3-substituted-4H-[1,2,3] triazolo[5,1-c][1,4]oxazin-6(7H)-ones from propargyl alcohols, chloroacetyl chloride, and sodium azide

An efficient, one-pot synthesis of 3-substituted-4H-[1,2,3]triazolo[5,1-c][1,4]oxazin-6(7H)-ones is developed via sequential esterification, substitution, and 1,3-dipolar cycloaddition processes of various propargyl alcohols, chloroacetyl chloride, and so

Chemoselective Hydroboration of Propargylic Alcohols and Amines Using a Manganese(II) Catalyst

The first manganese-catalyzed hydroboration of propargylic alcohols and amines as well as internal alkynes is reported. High regio- and stereoselectivity is achieved by applying 2 mol % of a manganese precatalyst based on the readily accessible bis(imino)pyridine ligand and MnCl2 as metal source. Propargylic alcohols and amines, as well as symmetric internal alkynes, were efficiently converted into the corresponding functionalized alkenes, which can serve as important and valuable intermediates for further synthetic applications such as cross-coupling reactions.

Rhodium(i)-catalyzed Pauson-Khand-type reaction using formic acid as a CO surrogate: An alternative approach for indirect CO2 utilization

Formic acid is found to be an ideal CO surrogate for the rhodium(i)-catalyzed Pauson-Khand-type (PK-type) reaction of various substituted 1,6-enynes to afford bicyclic cyclopentenones in moderate to good yields. High TON value of up to 263 and good results in the gram-scale experiment were also obtained, demonstrating the efficacy of this methodology. In addition, heterocyclic molecules of pharmaceutical importance were also furnished via inter- or intra-molecular hetero-PK-type reactions, further broadening the application of current strategy. In this protocol, formic acid was utilized as a bridging molecule for the conversion of CO2 to CO, since formic acid is manufactured via catalytic hydrogenation of CO2 and releases CO in the presence of acetic anhydride readily. Therefore, this methodology represents a green and indirect approach for chemical valorization of CO2 in the preparation of value-added compounds.