80235-01-4

Basic information

• Product Name: 3-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE
• Synonyms: 3-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE;3-CHLORO-7-AZAINDOLE;1H-Pyrrolo[2,3-b]pyridine, 3-chloro-
• CAS NO: 80235-01-4
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.58
• Product Categories: CHIRAL CHEMICALS;indole
• Mol File: 80235-01-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 168-170
• Boiling Point: 312.149 °C at 760 mmHg
• Flash Point: 171.662 °C
• Appearance: /
• Density: 1.425 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.703
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 5.98±0.20(Predicted)
• CAS DataBase Reference: 3-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE(80235-01-4)
• EPA Substance Registry System: 3-CHLORO-1H-PYRROLO[2,3-B]PYRIDINE(80235-01-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 80235-01-4(Hazardous Substances Data)

Usage

Uses

3-chloro-1H-pyrrolo[2,3-b]pyridine is a useful research chemical.

Chemical Properties

Solid

InChI:InChI=1/C7H5ClN2/c8-6-4-10-7-5(6)2-1-3-9-7/h1-4H,(H,9,10)

Upstream product

• 271-63-6 7-Azaindole 

Relevant articles and documents

A 3 bit halogen-substituted 7 - aza indole preparation method (by machine translation)

The invention discloses a three-position three-halogen-substituted 7 - aza indole preparation method, comprises the following steps: the 7 - aza indole dissolved in organic solvent, adding halogen source compound and catalyst, react under the catalysis of the catalyst, after the reaction, to obtain purified 3 bit halogen-substituted 7 - azaindole. The method uses a three step reaction method for preparing halogen-substituted 7 - azaindole, using multivariate composite catalyst system, the reaction conversion is high, a high degree of selectivity. And, the preparation method required mild reaction conditions, the safety of the raw materials, the reaction and the cost is low, and has high industrial production prospect. (by machine translation)

Simple and efficient procedures for selective preparation of 3-haloindoles and 2,3-dihaloindoles by using 1,3-dibromo-5,5-dimethylhydantoin and 1,3-dichloro-5,5-dimethylhydantoin

Simple and efficient synthetic procedures for the selective preparation of 3-bromo/3-chloroindoles and 2,3-dibromo/2,3-dichloroindoles by using 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) and 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) were developed. Using 1,4-dioxane as the solvent, a variety of indoles, treated with 0.55 equiv DBDMH/DCDMH, afford the corresponding 3-bromo/3-chloroindoles selectively in 82-99% yield. In 1,2-dichloroethane (DCE), a series of 2,3-dichloro/2,3-dibromoindoles were selectively obtained in 84-95% yield by treating with DBDMH/DCDMH. All the processes do not need extra catalysts, dry solvents, or harsh reaction conditions.

A practical synthesis of 2-((1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino)-5- fluoronicotinic acid

A practical synthesis of a key pharmaceutical intermediate, 2-[(1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino]-5-fluoronicotinic acid (1), is described. To introduce the aminomethyl moiety of 2 via a palladium-catalyzed cyanation/reduction sequence, a regioselective chlorination of 7-azaindole via the N-oxide was developed. A highly selective monodechlorination of 2,6-dichloro-5-fluoronicotinic acid was discovered to afford the nicotinic acid 3. The two building blocks 2 and 3 were then coupled to complete the preparation of 1.