80240-40-0

Basic information

• Product Name: 4-(4-Fluorophenyl)-1H-1,2,4-triazol-5(4H)-one
• Synonyms: 4-(4-Fluorophenyl)-1H-1,2,4-triazol-5(4H)-one;4-(4-Fluorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
• CAS NO: 80240-40-0
• Molecular Formula: C₈H₆FN₃O
• Molecular Weight: 179.15
• Mol File: 80240-40-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.437 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4-Fluorophenyl)-1H-1,2,4-triazol-5(4H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Fluorophenyl)-1H-1,2,4-triazol-5(4H)-one(80240-40-0)
• EPA Substance Registry System: 4-(4-Fluorophenyl)-1H-1,2,4-triazol-5(4H)-one(80240-40-0)

Safety Data

• Hazardous Substances Data: 80240-40-0(Hazardous Substances Data)

Usage

General Description

4-(4-Fluorophenyl)-1H-1,2,4-triazol-5(4H)-one is a chemical compound that belongs to the class of triazolone derivatives. It is a white solid that is soluble in organic solvents. 4-(4-Fluorophenyl)-1H-1,2,4-triazol-5(4H)-one has potential applications in the field of pharmaceuticals, agrochemicals, and materials science. It displays a range of biological activities and has been studied for its potential use as an antifungal, antibacterial, and antitumor agent. Additionally, it has been investigated for its potential as a building block in the synthesis of new compounds with unique properties and applications. Overall, 4-(4-Fluorophenyl)-1H-1,2,4-triazol-5(4H)-one is a versatile chemical with diverse potential uses in various industries.

Upstream product

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Downstream Products

• 155431-23-5 2-<(1R,2S)-2-(2,4-difluorophenyl)-2,3-epoxy-1-methylpropyl>-4-(4-fluorophenyl)-3(2H,4H)-1,2,4-triazolone 
• 1312809-81-6 1-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-fluorophenyl)-1H-1,2,4-triazol-5(4H)-one 
• 1346235-18-4 C₁₁H₁₁BrFN₃O 
• 1346235-38-8 C₁₅H₂₀FN₅O 
• 1346235-58-2 1-(3-(4-(2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl) piperazin-1-yl)propyl)-4-(4-fluorophenyl)-1H-1,2,4-triazol-5(4H)-one 

Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δDual Agonists for the Treatment of Nonalcoholic Steatohepatitis

Peroxisome proliferator-activator receptors α/δ(PPARα/δ) are regarded as potential therapeutic targets for nonalcoholic steatohepatitis (NASH). However, PPARα/δdual agonist GFT-505 exhibited poor anti-NASH effects in a phase III clinical trial, probably due to its weak PPARα/δagonistic activity and poor metabolic stability. Other reported PPARα/δdual agonists either exhibited limited potency or had unbalanced PPARα/δagonistic activity. Herein, we report a series of novel triazolone derivatives as PPARα/δdual agonists. Among them, compound H11 exhibited potent and well-balanced PPARα/δagonistic activity (PPARα EC50 = 7.0 nM; PPARδEC50 = 8.4 nM) and a high selectivity over PPARγ(PPARγEC50 = 1316.1 nM) in PPAR transactivation assays. The crystal structure of PPARδin complex with H11 revealed a unique PPARδ-agonist interaction. H11, which had excellent PK properties and a good safety profile, showed potent in vivo anti-NASH effects in preclinical models. Together, H11 holds a great promise for treating NASH or other inflammatory and fibrotic diseases.

NOVEL ARYL OR HETEROARYL TRIAZOLONE DERIVATIVES OR SALTS THEREOF, OR PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

The present technology provides aryl or heteroaryl triazolone derivatives or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and the use thereof. The aryl or heteroaryl triazolone derivatives or their pharmaceutically acceptable salts exhibit selective inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).

Design and synthesis of novel triazole antifungal derivatives by structure-based bioisosterism

The incidence of life-threatening fungal infections is increasing dramatically. In an attempt to develop novel antifungal agents, our previously synthesized phenoxyalkylpiperazine triazole derivatives were used as lead structures for further optimization. By means of structure-based bioisosterism, triazolone was used as a new bioisostere of oxygen atom. This type of bioisosteric replacement can improve the water solubility without loss of hydrogen-bonding interaction with the target enzyme. A series of triazolone-containing triazoles were rationally designed and synthesized. As compared with fluconazole, several compounds showed higher antifungal activity with broader spectrum, suggesting their potential for further evaluations.