80466-51-9

Basic information

• Product Name: 2-Propanol, 2-methyl-1-[(phenylmethyl)amino]-
• CAS NO: 80466-51-9
• Molecular Formula: C11H17NO
• Molecular Weight: 179.262
• Mol File: 80466-51-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Propanol, 2-methyl-1-[(phenylmethyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propanol, 2-methyl-1-[(phenylmethyl)amino]-(80466-51-9)
• EPA Substance Registry System: 2-Propanol, 2-methyl-1-[(phenylmethyl)amino]-(80466-51-9)

Safety Data

• Hazardous Substances Data: 80466-51-9(Hazardous Substances Data)

Upstream product

• 558-30-5 2-methyl-1,2-epoxypropane 
• 100-46-9 benzylamine 
• 598-26-5 dimethylketene 
• 100-52-7 benzaldehyde 
• 2854-16-2 1-Amino-2-methyl-propan-2-ol 

Downstream Products

• 1312608-02-8 ethyl 2-(benzyl(2-hydroxy-2-methylpropyl)amino)acetate 
• 1312608-23-3 2-(4-benzyl-6,6-dimethyl-2-oxomorpholin-3-yl)acetic acid 
• 1312608-15-3 tert-butyl 2-(4-benzyl-6,6-dimethyl-2-oxomorpholin-3-yl)acetate 
• 1312607-45-6 2-(4-benzyl-6,6-dimethyl-2-oxomorpholin-3-yl)-N-(4-isopropylphenyl)acetamide 
• 1400589-78-7 [(2S)-6,6-dimethyl-4-(phenylmethyl)-2-morpholinyl]methanol 
• 344868-41-3 1-dibenzylamino-2-methyl-propan-2-ol 
• 80466-52-0 2-amino-6-amino-5-nitropyrimidin-4(3H)-one 

Relevant articles and documents

Cyclic Sulfamidite as Simultaneous Protecting Group for Amino Alcohols: Development of a Mild Deprotection Protocol Using Thiophenol

This study describes the novel utility of cyclic sulfamidite as a simultaneous protecting group for 1,2- or 1,3-amino alcohols. An exceptionally mild and neutral condition for the removal of the cyclic sulfamidite was developed. The deprotection condition demonstrated a broad range of functional-group compatibility, including a substrate bearing a Z-enyne structure without any loss of double-bond stereochemistry.

2-(2-Oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents

From a fungicidal screen, we identified 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as fungicidal agents against Candida species, additionally characterized by antifungal activity against Aspergillus species. However, development of this series was hampered by low plasmatic stability. Introduction of a gem-dimethyl on the 6-position of the morpholin-2-one core led to considerable improvement in plasmatic stability while maintaining in vitro antifungal activity. Further optimization of the series resulted in the discovery of N-(biphenyl-3-ylmethyl)-2-(4-ethyl-6,6-dimethyl-2-oxomorpholin-3-yl)acetamide (87), which, in addition to fungicidal activity against Candida species, shows promising and broad antifungal in vitro activity against various fungi species, such as molds and dermatophytes. In vivo efficacy was also demonstrated in a murine model of systemic Candida albicans infection with a significant fungal load reduction in kidneys.

ANTIFUNGAL COMPOUNDS

The present invention relates to a series of novel compounds which have been shown to possess antifungal activity. The invention therefore relates to the new compounds, methods for their preparation, pharmaceutical compositions comprising them and to the compounds for use as a medicament, more in particular antifungal medicament.