80514-78-9Relevant articles and documents
TRITYLATION REACTIONS BASED ON METALLIC CATALYSIS
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Page/Page column 23-24, (2010/11/25)
The invention relates to a method for preparing tritylated compounds in which protic functional groups are protected with the triphenylmethyl group, method based on the homogeneous catalysis exercised by salts or metal complexes in organic solvents. The invention relates in particular to a method for the selective tritylation of some groups, obtained both directly and by selective detritylation, with methods based on metallic catalysis. The application to amino acids, typical substrates not suitable to be subjected as such to homogeneous tritylations in organic solvents, indicates the ability of the method to extend also to hydrophilic substrates. The method allows to obtain with high yield pertrityl amino acids, N-tritylamino acids or amino acids tritylated only in lateral chain, compounds which heretofore were either difficult to obtain in aqueous solvents or obtainable through indirect methods. All, in any case, are important intermediates in peptide synthesis.
PREAPARATION OF TRITYL DERIVATIVES OF AMINO ACIDS WITH THE AID OF THE SILYLATION REACTION
Rabinovich, A. K.,Karelskii, V. N.,Krysin. E. P.,Antonov, A. A.,Smirnov, M. B.,Chipens, G. I.
, p. 205 - 207 (2007/10/02)
A number of N-trityl-substituted amino acids (lysine, glutamine, tyrosine, valine, and proline) have been obtained with the aid of the silylation reaction.Bis(trimethylsilyl)acetamide was used as the silylating agent.The compounds were isolated with good yields and were distinguished by chromatographic homogeneity, and they were characterized by their angles of optical rotation, melting points, and elementary analyses.Their purity was checked by TLC and 13C NMR.