805232-79-5Relevant articles and documents
Further enolate alkylation studies of 2,5-dimethyl-3(2H)-furanone
Caine, Drury S.,Arant, Mark E.
, p. 2081 - 2086 (2007/10/03)
Heterocyclic ketones, such as 2,5-dimethyl-3(2H)-furanone, provide multifunctional intermediates to various compounds. One property of these that has proven useful is the ability to alkylate the γ′-position of the dienolate. This report demonstrates the versatility of γ′-dienolate substitutions as employed toward syntheses of certain natural products and highly reactive electrophiles provide the best substrates for efficient substitution.