80582-39-4

Basic information

• Product Name: (S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL
• Synonyms: (S)-BETA-(3,4-DIMETHOXYPHENYL)ALANINOL;(S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL;(S)-2-amino-3-(3,4-dimethoxyphenyl)propan-1-ol;REF DUPL: (S)-beta-(3,4-dimethoxyphenyl)alaninol;(S)-b-AMino-3,4-diMethoxybenzenepropanol
• CAS NO: 80582-39-4
• Molecular Formula: C₁₁H₁₇NO₃
• Molecular Weight: 211.26
• Mol File: 80582-39-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL(80582-39-4)
• EPA Substance Registry System: (S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL(80582-39-4)

Safety Data

• Hazardous Substances Data: 80582-39-4(Hazardous Substances Data)

Usage

Description

(S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL, a chemical compound with the molecular formula C12H19NO3, is an amino alcohol featuring a chiral center, which results in two enantiomeric forms. (S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL is a derivative of phenylpropanolamine, known for its sympathomimetic properties and past use as a decongestant and appetite suppressant. Its chemical structure includes a substituted benzene ring and an amino group attached to a three-carbon chain, which has been investigated for potential pharmacological activities, such as interactions with adrenergic receptors and its role as a drug lead in developing new therapeutic agents.

Uses

Used in Pharmaceutical Industry:
(S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL is used as a drug lead for the development of new therapeutic agents due to its potential pharmacological activities, including interactions with adrenergic receptors.
Used in Research and Development:
In the field of medicinal chemistry, (S)-3-AMINO-3-(3,4-DIMETHOXY-PHENYL)-PROPAN-1-OL is used as a compound of interest for studying its interactions with biological targets, which may lead to the discovery of novel treatments for various conditions.

Upstream product

• 78083-80-4 (S)-2-amino-3-(3,4-dimethoxyphenyl)propionic acid methyl ester 
• 32161-30-1 (S)-3,4-dimethoxyphenylalanine 
• 75-77-4 chloro-trimethyl-silane 
• 59-92-7 levodopa 
• 53053-92-2 N-formyl-3,4-dimethoxy-L-phenylalanine 

Downstream Products

• 105779-71-3 (S)-(-)-[2-(3,4-dimethoxyphenyl)-1-hydroxymethylethyl]carbamic acid tert-butyl ester 
• 406195-56-0 1-[(1R)-2-(3,4-dimethoxyphenyl)-1-(hydroxymethyl)ethyl]tetrahydro-1H-pyrrole-2,5-dione 
• 489420-99-7 (3S,6aS,10aR)-3-{[3,4-di(methoxy)phenyl]methyl}perhydro[1,3]oxazolo[2,3-1]indol-5-one 
• 741266-28-4 C₂₁H₂₇NO₆ 
• 860792-53-6 (3S,7R,8R,8aS)-3-(3,4-dimethoxybenzyl)-8-ethyl-7-(methoxycarbonylmethyl)-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 909281-78-3 (3S,7R,8aS)-3-(3,4-dimethoxybenzyl)-7-(methoxycarbonylmethyl)-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 944796-54-7 (3S,8R,8aS)-3-(3,4-dimethoxybenzyl)-8-ethyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 944796-55-8 (3S,8S,8aR)-3-(3,4-dimethoxybenzyl)-8-ethyl-5-oxo-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine 
• 944796-76-3 phenyl (2R,6S,11bR)-9,10-dimethoxy-2-(methoxycarbonylmethyl)-4-oxo-1,2,3,6,7,11b-hexahydrobenzo[a]quinolizine-6-carboselenoate 
• 105740-21-4 (R)-2-(tert-butoxycarbonylamino)-1-(3,4-dimethoxyphenyl)-4-pentene 
• 112276-39-8 (S)-4-(tert-butoxycarbonylamino)-5-(3,4-dimethoxyphenyl)-1-pentanol 
• 110469-82-4 [(R)-1-(3,4-Dimethoxy-benzyl)-4-iodo-butyl]-carbamic acid tert-butyl ester 
• 105740-20-3 (R)-6-Amino-2,7-bis-(3,4-dimethoxy-phenyl)-2-isopropyl-heptanenitrile 
• 112276-40-1 Methanesulfonic acid (R)-4-tert-butoxycarbonylamino-5-(3,4-dimethoxy-phenyl)-pentyl ester 

Relevant articles and documents

NOVEL INDOLE AND PYRROLOPYRIDINE AMIDES

The present invention relates to indole and pyrrolopyridine amide derivatives of formula (I) wherein R1, R 2, R 3, U, V, W, X, Y, Z and ring A are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as orexin receptor antagonists.

Facile and highly stereoselective synthesis of the tetracyclic erythrinane core

A highly stereoselective synthesis of the tetracyclic core of the Erythrina alkaloids is reported through the application of a Meyers bicyclic lactam template.

Tetrahydroisoquinoline derivatives

Compounds of the formula STR1 wherein R1 and R2 and each independently --H or lower alkoxy; R3 and R4 are each independently lower alkyl; and R5 and R6 are each --OCH3, or together form --OCH2 O-- or --OCH2 CH2 O--, and pharmaceutically acceptable acid addition salts thereof are prepared by cyclizing, deoxygenating, coupling, or hydrogenating the intermediates disclosed herein.