8068-28-8

Basic information

• Product Name: COLISTIN METHANESULFONATE SODIUM SALT
• Synonyms: COLIMYCIN SODIUM METHANESULFONATE;COLISTIN METHANESULFONATE SODIUM SALT;COLISTIN SODIUM METHANESULFONATE;(METHANESULFONIC ACID DERIVATIVE OF POLYMYXIN E) SODIUM SALT;POLYMYXIN E SODIUM METHANESULFONATE;colimycinm;colistinat;colistinmethanesulfonicacid,sodiumsalt
• CAS NO: 8068-28-8
• Molecular Formula: C58H105N16Na5O28S5
• Molecular Weight: 1749.81855
• EINECS: 232-516-9
• Product Categories: COLOMYCIN
• Mol File: 8068-28-8.mol
• Article Data: 0

Chemical Properties

• Appearance: white to faintly beige/
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble10mg/mL
• Water Solubility: Freely soluble in water
• Merck: 13,2503
• CAS DataBase Reference: COLISTIN METHANESULFONATE SODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: COLISTIN METHANESULFONATE SODIUM SALT(8068-28-8)
• EPA Substance Registry System: COLISTIN METHANESULFONATE SODIUM SALT(8068-28-8)

Safety Data

• RIDADR: 3249
• WGK Germany: 2
• RTECS: GH1650000
• F: 3
• TSCA: Yes
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 8068-28-8(Hazardous Substances Data)

Usage

Description

Colistin Methanesulfonate Sodium Salt, also known as Colistin Sodium Methane Sulfate, is a polymyxin antibiotic derivative. It is a mixture where R = H or Me, and each of the primary amino groups is converted to the corresponding aminomethanesulfonic acid sodium salt, commonly by the action of formaldehyde followed by sodium bisulfite. Colistin Methanesulfonate Sodium Salt is a white or almost white, hygroscopic powder. It is used in the treatment of severe infections, particularly of multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii.

Uses

Used in Pharmaceutical Industry:
Colistin Methanesulfonate Sodium Salt is used as an antibiotic for the treatment of severe infections caused by multidrug-resistant Gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii. It is effective due to its ability to permeabilize bacterial cell membranes, leading to cell death.
Used in Research:
Colistin Methanesulfonate Sodium Salt is used in research to study mannose-resistant haemagglutination, which can provide insights into the mechanisms of bacterial infections and resistance.
Used in Cystic Fibrosis Treatment Research:
In the context of cystic fibrosis, Colistin Methanesulfonate Sodium Salt is used to study effective treatments for P. aeruginosa infections, which are a common and serious complication for these patients.
Used in Critical Care Research:
Colistin Methanesulfonate Sodium Salt is used in research to study the pharmacokinetics and bronchoalveolar lavage (BAL) concentration of colistin in critically ill patients, helping to optimize dosing and treatment strategies for severe infections in this population.
Brand Name:
Coly-Mycin (Monarch)

Biological Activity

colistin methanesulfonate is an inactive prodrug of colistin (also known as polymyxin e), which is an antibiotic with effect against most gram-negative bacteria, but also causes nephro- and neurotoxicity [1]. colistin is produced by certain strains of the bacteria paenibacillus polymyxa, and belongs to the class of polypeptide antibiotics known as polymyxins.in vitro: studying the time-kill kinetics of colistin methanesulfonate against a type culture of pseudomonas aeruginosa found that 8.0 or 32 mg/l colistin methanesulfonate began killing at approximately 90 or 30 min, and the mean auc0-240 values were 186.3±6.0 and 90.4±4.1, respectively [2]. besides, by investigation among mucoid and nonmucoid strains of pseudomonas aeruginosa isolated from patients with cystic fibrosis, colistin methanesulfonate was found to require a concentration of 16 times the mic to achieve complete killing within 24 h [3].

Safety Profile

Human poison by intramuscular route. Experimental poison by intramuscular, intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. An experimental teratogen. Human systemic effects by intramuscular route: convulsions or effect on seizure threshold, change in motor activity, change in lrldney tubules, and urine volume decrease or anuria. Experimental reproductive effects. Used as an antibiotic. When heated to decomposition it emits very toxic fumes of NOx, SOx, and NazO

references

[1] nation r l, li j. colistin in the 21st century.[j]. current opinion in infectious diseases, 2009, 22(6): 535-543.[2] bergen p j, li j, rayner c r, et al. colistin methanesulfonate is an inactive prodrug of colistin against pseudomonas aeruginosa.[j]. antimicrobial agents and chemotherapy, 2006, 50(6): 1953-1958.[3] li j, turnidge j d, milne r w, et al. in vitro pharmacodynamic properties of colistin and colistin methanesulfonate against pseudomonas aeruginosaisolates from patients with cystic fibrosis[j]. antimicrobial agents and chemotherapy, 2001, 45(3): 781-785.