80685-23-0 Usage
Description
8-Hydroxyacyclovir is a derivative of the anti-viral drug Acyclovir (ACV), which is commonly used to treat herpes simplex virus infections. It is formed by the addition of a hydroxyl group to the ACV molecule, resulting in enhanced antiviral activity and improved pharmacokinetic properties.
Uses
Used in Pharmaceutical Industry:
8-Hydroxyacyclovir is used as an antiviral agent for the treatment of herpes simplex virus infections. It exhibits increased antiviral activity compared to its parent compound, Acyclovir, due to its improved pharmacokinetic properties and ability to penetrate cellular barriers more effectively.
Additionally, 8-Hydroxyacyclovir may be used as a potential candidate for the development of new antiviral drugs, given its enhanced activity and potential to overcome drug resistance in viral infections.
Used in Environmental Applications:
8-Hydroxyacyclovir is used as a target compound for the improvement of biological treatment processes in sewage treatment plants. The presence of Acyclovir, the parent compound, has been detected in natural water sources at concentrations ranging from ng L-1 to μg L-1, indicating the need for more efficient biodegradation methods. By focusing on the degradation of 8-Hydroxyacyclovir, researchers can develop more effective strategies to remove ACV and its derivatives from wastewater, reducing their environmental impact.
Check Digit Verification of cas no
The CAS Registry Mumber 80685-23-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,6,8 and 5 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 80685-23:
(7*8)+(6*0)+(5*6)+(4*8)+(3*5)+(2*2)+(1*3)=140
140 % 10 = 0
So 80685-23-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H10BrN5O3/c9-7-11-4-5(12-8(10)13-6(4)16)14(7)3-17-2-1-15/h15H,1-3H2,(H3,10,12,13,16)
80685-23-0Relevant articles and documents
Nucleic Acid Related Compounds. 47. Synthesis and Biological Activities of Pyrimidine and Purine "Acyclic" Nucleoside Analogues
Robins, Morris J.,Hatfield, Peter W.,Balzarini, Jan,Clercq, Eric De
, p. 1486 - 1492 (2007/10/02)
Various acyclic, i.e., (2-hydroxyethoxy)methyl and (2-acetoxyethoxy)methyl, analogues of pyrimidine and purine nucleosides have been prepared evaluated for their antiviral, antimetabolic, and cytotoxic properties.All of the pyrimidine analogues, including (E)-5-(2-bromovinyl)-1-uracil (12) and its O-acetyl derivative (13), were virtually devoid of antiviral, cytotoxic, and antimetabolic activities.However, several of the 8-substituted derivatives of 9-guanine (acyclovir) had higher antiviral specificity in vitro than the parent drug.The 8-methyl-, 8-amino-, 8-bromo-, and 8-iodoacyclovir derivatives have activities worthy of further investigation.
