80742-11-6

Basic information

• Product Name: 6-Methyl-2,4-bis-(2-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-5-carbonsaeuremethylester
• CAS NO: 80742-11-6
• Molecular Weight: 398.375
• Mol File: 80742-11-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 572.8±50.0 °C(Predicted)
• Density: 1.339±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 6-Methyl-2,4-bis-(2-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-5-carbonsaeuremethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methyl-2,4-bis-(2-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-5-carbonsaeuremethylester(80742-11-6)
• EPA Substance Registry System: 6-Methyl-2,4-bis-(2-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-5-carbonsaeuremethylester(80742-11-6)

Safety Data

• Hazardous Substances Data: 80742-11-6(Hazardous Substances Data)

Usage

Description

6-Methyl-2,4-bis-(2-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-5-carbonsaeuremethylester is a chemical compound that is an impurity of Nifedipine, a dihydropyridine calcium channel blocker. It is also used as an antihypertensive and antianginal agent.

Uses

Used in Pharmaceutical Industry:
6-Methyl-2,4-bis-(2-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-5-carbonsaeuremethylester is used as an impurity in the production of Nifedipine, a calcium channel blocker that is used to treat hypertension, angina, and certain heart rhythm disorders.
Used as an Antihypertensive Agent:
6-Methyl-2,4-bis-(2-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-5-carbonsaeuremethylester is used as an antihypertensive agent to help lower blood pressure and reduce the risk of cardiovascular diseases.
Used as an Antianginal Agent:
6-Methyl-2,4-bis-(2-nitrophenyl)-1,2,3,4-tetrahydropyrimidin-5-carbonsaeuremethylester is used as an antianginal agent to help relieve chest pain and improve blood flow to the heart muscle.

Upstream product

• 15768-07-7 methyl 2-benzylidene-3-oxobutanoate 
• 552-89-6 2-nitro-benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 21731-17-9 methyl 3-aminocrotonate 

Downstream Products

• 80742-22-9 4-methyl-2,6-bis-(2-nitroso-phenyl)-pyrimidine-5-carboxylic acid methyl ester 
• 80742-26-3 C₁₉H₁₇N₅O₇ 
• 80742-28-5 C₁₉H₁₇N₅O₇ 
• 30160-03-3 methyl 2-methylquinoline-3-carboxylate 

Relevant articles and documents

Stability investigations of alkyl 2,4-bisaryl-6-methyl-1,2,3,4- tetrahydropyrimidine-5-carboxylates

The tetrahydropyrimidines (THPM) with an 4-(2-nitrophenyl) substituent 14 react with UV-A-light to yield the pyrimido[1,6-b]indazoles 16 and the cyclic hydroxamic acid 20 as a by-product. Irradiation of the 2,4-bis(2- nitrophenyl) THMP 2 do not give the 2,4-bis(2-nitrosophenyl)pyrimidine 26, but a mixture of the pyrimido[1,6-b]- and -[1,2-b]-indazoles 27 and 28. The products obtained by oxidation and reduction of the THPM are reported including the synthesis of pyrido[5,4-b]quinolines.

1,3-Dicarbonyl compounds, XVIII. Alkyl 2,4-diaryl-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates

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