807667-27-2

Basic information

• Product Name: 2-chloro-3-(4-methoxyphenyl)propanal
• Synonyms: 2-chloro-3-(4-methoxyphenyl)propanal
• CAS NO: 807667-27-2
• Molecular Weight: 198.649
• Mol File: 807667-27-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 2-chloro-3-(4-methoxyphenyl)propanal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-3-(4-methoxyphenyl)propanal(807667-27-2)
• EPA Substance Registry System: 2-chloro-3-(4-methoxyphenyl)propanal(807667-27-2)

Safety Data

• Hazardous Substances Data: 807667-27-2(Hazardous Substances Data)

Upstream product

• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 104-94-9 4-methoxy-aniline 
• 53484-50-7 (E)-p-methoxy-cinnamyl alcohol 
• 107-02-8 acrolein 
• 20401-88-1 3-(4-methoxyphenyl)propional 
• 4346-59-2 para-methoxyphenyldiazonium chloride 

Downstream Products

• 1029712-74-0 2-(4-fluorophenyl)-7-(4-methoxybenzyl)imidazo[1,2-b][1,2,4]triazine 
• 1029712-77-3 6-(4-fluorophenyl)-3-(4-methoxybenzyl)imidazo[1,2-a]pyrimidine 
• 304895-22-5 2-chloro-N-[5-[(4-methoxyphenyl)methyl]thiazol-2-yl]acetamide 

Relevant articles and documents

Synthesis and BK channel-opening activity of 2-amino-1,3-thiazole derivatives

A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.

Carbene-Catalyzed α-Carbon Amination of Chloroaldehydes for Enantioselective Access to Dihydroquinoxaline Derivatives

An NHC-catalyzed α-carbon amination of chloroaldehydes was developed. Cyclohexadiene-1,2-diimines are used as amination reagents and four-atom synthons. Our reaction affords optically enriched dihydroquinoxalines that are core structures in natural products and synthetic bioactive molecules.

Trifluoromethylthiolation of α-Chloroaldehydes: Access to Quaternary SCF3-Containing Centers

In this study, a straightforward methodology was developed to access quaternary α-trifluoromethylthiolated chloroaldehydes. Using the Munavalli reagent as the electrophilic SCF3 source, a base-catalyzed trifluoromethylthiolation reaction with a panel of α-chloroaldehydes was successfully achieved under mild reaction conditions. The α-trifluoromethylthiolated chloroaldehydes were obtained in moderate to high yields (up to 88 %). This approach demonstrated a good functional-group tolerance and offered access to highly functionalized quaternary trifluoromethylthiolated aldehydes, inaccessible so far. The development of an enantioselective version was investigated by using a chiral phase-transfer catalyst, giving the enantioenriched product in moderate enantiomeric excess.