80839-90-3

Basic information

• Product Name: N-Acetyl-S-(4-nitrobenzyl)-L-cysteine
• CAS NO: 80839-90-3
• Molecular Weight: 298.32
• Mol File: 80839-90-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-Acetyl-S-(4-nitrobenzyl)-L-cysteine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Acetyl-S-(4-nitrobenzyl)-L-cysteine(80839-90-3)
• EPA Substance Registry System: N-Acetyl-S-(4-nitrobenzyl)-L-cysteine(80839-90-3)

Safety Data

• Hazardous Substances Data: 80839-90-3(Hazardous Substances Data)

Upstream product

• 99-99-0 1-methyl-4-nitrobenzene 
• 616-91-1 N-acetylcystein 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 100-14-1 4-nitrobenzyl chloride 
• 6341-94-2 S-p-nitro-benzyl-L-cysteine 
• 108-24-7 acetic anhydride 

Relevant articles and documents

Targeted Delivery of Persulfides to the Gut: Effects on the Microbiome

Persulfides (R?SSH) have been hypothesized as potent redox modulators and signaling compounds. Reported herein is the synthesis, characterization, and in vivo evaluation of a persulfide donor that releases N-acetyl cysteine persulfide (NAC-SSH) in response to the prokaryote-specific enzyme nitroreductase. The donor, termed NDP-NAC, decomposed in response to E. coli nitroreductase, resulting in release of NAC-SSH. NDP-NAC elicited gastroprotective effects in mice that were not observed in animals treated with control compounds incapable of persulfide release or in animals treated with Na2S. NDP-NAC induced these effects by the upregulation of beneficial small- and medium-chain fatty acids and through increasing growth of Turicibacter sanguinis, a beneficial gut bacterium. It also decreased the populations of Synergistales bacteria, opportunistic pathogens implicated in gastrointestinal infections. This study reveals the possibility of maintaining gut health or treating microbiome-related diseases by the targeted delivery of reactive sulfur species.