80944-48-5

Basic information

• Product Name: 2-propylisonicotinamide
• Synonyms: 2-propylisonicotinamide;2-Propyl-4-pyridinecarboxamide
• CAS NO: 80944-48-5
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.20438
• EINECS: 279-634-7
• Product Categories: Pharmaceutical Raw Materials
• Mol File: 80944-48-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 293.2°C at 760 mmHg
• Flash Point: 131.1°C
• Appearance: /
• Density: 1.089g/cm³
• Vapor Pressure: 0.00175mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: 2-propylisonicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-propylisonicotinamide(80944-48-5)
• EPA Substance Registry System: 2-propylisonicotinamide(80944-48-5)

Safety Data

• Hazardous Substances Data: 80944-48-5(Hazardous Substances Data)

Usage

Description

2-Propylisonicotinamide, also known as 2-PIA, is an isonicotinamide derivative with the molecular formula C11H15N2O. It has been studied for its potential therapeutic effects, including anti-inflammatory properties and neuroprotective capabilities.

Uses

Used in Pharmaceutical Industry:
2-Propylisonicotinamide is used as an anti-inflammatory agent for its potential to treat conditions such as rheumatoid arthritis and inflammatory bowel disease. Its anti-inflammatory properties make it a promising candidate for managing inflammatory conditions.
Used in Neuroprotection Research:
2-Propylisonicotinamide is used as a neuroprotective agent in research settings, with studies suggesting its ability to protect against neuronal damage. This potential use highlights its promise in the development of treatments for neurodegenerative diseases and conditions involving neuronal injury.

InChI:InChI=1/C9H12N2O/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)

Upstream product

• 1531-17-5 ethyl 2-propylisonicotinate 
• 100129-70-2 2-chloro-6-propyl-isonicotinic acid ethyl ester 
• 29840-73-1 2-bromopyridine-4-carboxamide 
• 77047-87-1 isopropyl zinc bromide 
• 156567-57-6 propylzinc bromide 

Downstream Products

• 33744-19-3 2-propylpyridine-4-carbonitrile 
• 14222-60-7 prothionamide 

Relevant articles and documents

Efficient analoging around ethionamide to explore thioamides bioactivation pathways triggered by boosters in Mycobacterium tuberculosis

Ethionamide is a key antibiotic prodrug of the second-line chemotherapy regimen to treat tuberculosis. It targets the biosynthesis of mycolic acids thanks to a mycobacterial bioactivation carried out by the Baeyer-Villiger monooxygenase EthA, under the control of a transcriptional repressor called EthR. Recently, the drug-like molecule SMARt-420, which triggers a new transcriptional regulator called EthR2, allowed the derepression a cryptic alternative bioactivation pathway of ethionamide. In order to study the bioactivation of a collection of thioisonicotinamides through the two bioactivation pathways, we developed a new two-step chemical pathway that led to the efficient synthesis of eighteen ethionamide analogues. Measurements of the antimycobacterial activity of these derivatives, used alone and in combination with boosters BDM41906 or SMARt-420, suggest that the two different bioactivation pathways proceed via the same mechanism, which implies the formation of similar metabolites. In addition, an electrochemical study of the aliphatic thioisonicotinamide analogues was undertaken to see whether their oxidation potential correlates with their antitubercular activity measured in the presence or in the absence of the two boosters.