81-14-1 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 81-14-1 differently. You can refer to the following data:
1. White to light yellow crystal powde
2. It forms yellowish crystals with a sweet, very
persistent, slightly animal musk odor.Musk ketone is prepared by Friedel–Crafts
acetylation of 1,3-dimethyl-5-tert-butylbenzene and nitration of the resulting 2,6-
dimethyl-4-tert-butylacetophenone with nitric acid.Musk ketone is widely used as a fixative in blossom and fantasy compositions.
Occurrence
Has apparently not been reported to occur in nature.
Uses
Musk ketone is used as fragrance and fixative in after-shave lotions, perfumes, ete.
Preparation
Nitration of the corresponding benzene derivative (Bedoukian, 1967).
General Description
Light yellow crystalline solid. Insoluble in water.
Air & Water Reactions
Insoluble in water.
Fire Hazard
Flash point data is not available for Musk ketone, however, Musk ketone is probably combustible.
Flammability and Explosibility
Notclassified
Purification Methods
Purify the ketone by recrystallisation from MeOH. It has a strong odour of musk and is used in perfumery. [Fuson et al. J Org Chem 12 587 1947, Beilstein 7 IV 808.]
Check Digit Verification of cas no
The CAS Registry Mumber 81-14-1 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 1 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 81-14:
(4*8)+(3*1)+(2*1)+(1*4)=41
41 % 10 = 1
So 81-14-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H30O/c1-15-12-10-8-6-4-2-3-5-7-9-11-13-16(17)14-15/h15H,2-14H2,1H3
81-14-1Relevant articles and documents
Modified and convenient methods for the preparation of some nitro musks
Safaei-Ghomi, Javad,Bamoniri, Abdolhamid
, p. 188 - 191 (2007/10/03)
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Non-acid synthesis of nitro musks based on the ozone-mediated nitration using nitrogen dioxide
Suzuki, Hitomi,Hisatome, Kaori,Nonoyama, Nobuaki
, p. 1291 - 1293 (2007/10/03)
Three nitro musks, musk xylol 1, musk ketone 2 and musk ambrette 3, were prepared in good to moderate yield by direct polynitration of the respective aromatic materials with nitrogen dioxide in the presence of ozone.