81039-90-9

Basic information

• Product Name: (RS)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-(4-aminophenyl)-α-phenylacetate
• Synonyms: (RS)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-(4-aminophenyl)-α-phenylacetate
• CAS NO: 81039-90-9
• Molecular Weight: 352.433
• Mol File: 81039-90-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (RS)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-(4-aminophenyl)-α-phenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-(4-aminophenyl)-α-phenylacetate(81039-90-9)
• EPA Substance Registry System: (RS)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-(4-aminophenyl)-α-phenylacetate(81039-90-9)

Safety Data

• Hazardous Substances Data: 81039-90-9(Hazardous Substances Data)

Upstream product

• 81381-90-0 α-hydroxy-α-(4-aminophenyl)-α-phenylacetic acid 
• 81039-78-3 ethyl α-hydroxy-α-(4-aminophenyl)-α-phenylacetate 
• 25333-42-0 (R)-quinuclidin-3-ol 
• 3684-26-2 (S)-quinuclidin-3-ol 
• 81039-87-4 ethyl α-hydroxy-α-(4-nitrophenyl)-α-phenylacetate 
• 88000-54-8 (R,S)-α-hydroxy-α-(4-nitrophenyl)-α-phenylacetic acid 
• 31029-96-6 1-(4-aminophenyl)-2-phenylethane-1,2-dione 
• 88000-53-7 α-hydroxy-4-nitro-α-phenylbenzeneacetonitrile 
• 1144-74-7 4-nitrobenzophenone 

Downstream Products

• 81381-92-2 (RS)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>phenyl>-α-phenylacetate 
• 81381-93-3 IQNB 
• 81381-92-2 (R)-(-)-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>pheny>-α-phenylacetate 
• 81381-92-2 (S)-(+)-1-azabicyclo<2.2.2>oct-3-yl (RS)-α-hydroxy-α-<4-<2-(3-methylpiperidin-1-yl)-1,2-diazaethylen-1-yl>pheny>-α-phenylacetate 
• 88000-52-6 4-[(1-Aza-bicyclo[2.2.2]oct-3-yloxycarbonyl)-hydroxy-phenyl-methyl]-benzenediazonium; chloride 

Relevant articles and documents

Synthesis and evaluation of radioiodinated derivatives of 1-azabicyclo[2.2.2]oct-3-yl α-hydroxy-α-(4-iodophenyl)-α-phenylacetate as potential radiopharmaceuticals

Two derivatives of (RS)-1-azabicyclo[2.2.2]oct-3-yl (RS)-α-hydroxy-α-(4-iodophenyl)-α-phenylacetate and three partially resolved (R)- or (S)-1-azabicyclo[2.2.2]oct-3-yl (RS)-α-hydroxy-α-(4-iodophenyl)-α-phenylacetates labeled with no carrier added iodine-125 and iodine-123 were synthesized by the Wallach triazene approach. We have found that this approach is necessary to obtain no carrier added labeling and gives far better results than the direct electrophilic iodination. The obtained yields were 7 to 18% when using iodine-123 (yield dependent on the source of iodide) and up to 17% for iodine-123 (yield dependent on the source of iodide) and up to to 17% for iodine-125 labeled compounds. Our preliminary distribution studies indicate that one derivative localizes in the organs known to have a large concentration of muscarinic receptors and that this localization is due to binding to those receptors.