81087-59-4

Basic information

• Product Name: 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolidinedione
• Synonyms: 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolidinedione
• CAS NO: 81087-59-4
• Molecular Formula: C₁₉H₁₇ClN₂O₄
• Molecular Weight: 372.80228
• Mol File: 81087-59-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.334g/cm³
• Refractive Index: 1.606
• CAS DataBase Reference: 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolidinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolidinedione(81087-59-4)
• EPA Substance Registry System: 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolidinedione(81087-59-4)

Safety Data

• Hazardous Substances Data: 81087-59-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H17ClN2O4/c1-4-26-18(24)15-10(2)9-13-16(11(15)3)17(23)22(19(25)21-13)14-8-6-5-7-12(14)20/h5-9H,4H2,1-3H3,(H,21,25)

Upstream product

• 3320-83-0 o-chlorophenyl isocyanate 
• 67467-27-0 2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid 

Downstream Products

• 81087-79-8 3-(2-Chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1-(2-pyrrolidin-1-yl-ethyl)-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-76-5 3-(2-Chloro-phenyl)-5,7-dimethyl-1-(2-morpholin-4-yl-ethyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 
• 81088-54-2 3-(2-Chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1-pyridin-2-ylmethyl-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-63-0 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-[3-(N-benzyl-N-methylamino)propyl]-2,4(1H, 3H)-quinazolinedione 
• 136743-87-8 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N-phthaloylamino)ethyl-2,4-(1H,3H)-quinazolinedione 
• 136743-80-1 3-(2-Chloro-phenyl)-1-[2-(4-ethoxycarbonyl-piperazin-1-yl)-ethyl]-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 
• 136743-88-9 3-(2-Chloro-phenyl)-1-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 136743-78-7 3-(2-Chloro-phenyl)-1-(3-cyano-propyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 136743-89-0 3-(2-Chloro-phenyl)-1-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-78-7 3-(2-Chlorophenyl)-6-ethoxycarbonyl-1-(3-ethoxycarbonylpropyl)-5,7-dimethyl-2,4(1H,3H)-quinazolinedione 
• 81087-77-6 1-tert-Butoxycarbonylmethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 136743-86-7 1-Benzyloxycarbonylmethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-75-4 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-<2-(1-piperidinyl)ethyl>-2,4(1H,3H)-quinazolinedione 
• 81088-52-0 1-Benzyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 

Relevant articles and documents

Studies on hypotensive agents. Synthesis of 1-substituted 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)- quinazolinediones

3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)- quinazolinedione was newly prepared. 1-Hydrogen atoms of the compound were variously substituted in order to test for their hypotensive activities on relaxing effects of the blood vessels. The compounds with 2-(1-pyrrolidinyl ethyl, 2-(1-piperidinyl)ethyl, 3-(dimethylamino)propyl, and 3-(N-benzyl-N-methylamino)propyl moieties showed significant activity. The 2-(1-piperidinyl)ethyl compound possessed activity approximately 23 times more potent than papaverine, however, it was less potent than cinnarizine.