81107-97-3

Basic information

• Product Name: 2-BROMO-4-(TRIFLUOROMETHYL)PHENOL
• Synonyms: 2-BROMO-4-(TRIFLUOROMETHYL)PHENOL;BUTTPARK 180\07-84;3-Bromo-4-hydroxybenzotrifluoride;2-Bromo-4-(trifluoromethyl)phenol, 2-Bromo-alpha,alpha,alpha-trifluoro-p-cresol
• CAS NO: 81107-97-3
• Molecular Formula: C₇H₄BrF₃O
• Molecular Weight: 241.01
• Mol File: 81107-97-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 196.7 °C at 760 mmHg
• Flash Point: 72.8 °C
• Appearance: Brown/Liquid
• Density: 1.752 g/cm³
• Vapor Pressure: 0.28mmHg at 25°C
• Refractive Index: 1.4960 to 1.5000
• Storage Temp.: Room temperature.
• PKA: 7.03±0.18(Predicted)
• CAS DataBase Reference: 2-BROMO-4-(TRIFLUOROMETHYL)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-(TRIFLUOROMETHYL)PHENOL(81107-97-3)
• EPA Substance Registry System: 2-BROMO-4-(TRIFLUOROMETHYL)PHENOL(81107-97-3)

Safety Data

• Hazardous Substances Data: 81107-97-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H4BrF3O/c8-5-3-4(7(9,10)11)1-2-6(5)12/h1-3,12H

Upstream product

• 402-45-9 4-hydroxybenzotrifluoride 
• 68322-84-9 2-bromo-1-fluoro-4-(trifluoromethyl)benzene 

Downstream Products

• 142167-36-0 2-hydroxy-5-(trifluoromethyl)benzonitrile 
• 210039-65-9 2-hydroxy-5-(trifluoromethyl)benzaldehyde 
• 200956-54-3 2-bromo-1-isopropoxy-4-trifluoromethylbenzene 
• 1072073-78-9 2-allyl-6-bromo-4-(trifluoromethyl)phenol 
• 200956-32-7 1-(benzyloxy)-2-bromo-4-(trifluoromethyl)benzene 
• 934495-35-9 2-bromo-1-ethoxy-4-(trifluoromethyl)benzene 
• 67589-15-5 1-(2-hydroxy-5-(trifluoromethyl)phenyl)ethan-1-one 
• 779331-60-1 tert-butyl (2-bromo-4-trifluoromethylphenoxy)acetate 
• 1047657-72-6 1-benzyl-3-{[2-bromo-4-(trifluoromethyl)phenoxy]methyl}-2,5-dihydro-1H-pyrrole 
• 1259312-92-9 4-(2-bromo-4-(trifluoromethyl)phenoxy)-6-methyl-2-pyrone 
• 1358527-54-4 2-(2-bromo-4-(trifluoromethyl)phenoxy)methylfuran 
• 1379658-48-6 rac-1-(2-bromo-4-(trifluoromethyl)phenoxy)-4-(2-phenoxyphenyl)but-3-yn-2-ol 
• 1379658-81-7 2-(2-bromo-4-(trifluoromethyl)phenoxy)ethanol 
• 1412761-61-5 trimethyl(2-phenoxy-5-(trifluoromethyl)phenyl)silane 

Relevant articles and documents

Macrocyclic Modulators of the Ghrelin Receptor

The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.

Direct Conversion of Haloarenes to Phenols under Mild, Transition-Metal-Free Conditions

A high-yielding and practical method for the synthesis of phenols from electron-deficient haloarenes and heteroarenes has been developed. The products are formed from acetohydroxamic acid as the hydroxide source via a novel SNAr reaction/Lossen rearrangement sequence. Notably, these reactions employ inexpensive and air-stable reagents, require no special handling, occur under mildly basic conditions, and form products in high yields in the presence of electrophilic and protic functionality. The utility of this methodology is demonstrated by the high-yielding hydroxylation of two base-sensitive complex substrates.

2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS

The present invention provides novel phenoxyacetic acids useful for the prevention and treatment of inflammatory disorders, including those affecting the respiratory system and skin. The compounds are of the general formula (I):