81135-38-8

Basic information

• Product Name: L-Valine, N-methyl-, phenylmethyl ester
• Synonyms: (S)-3-Methyl-2-methylamino-butyric acid benzyl ester;N-Me-Val-OBzl;H-MeVal-OBzl;N-methylvaline-O-benzyl ester;N-methylvaline benzyl ester
• CAS NO: 81135-38-8
• Molecular Formula: C13H19NO2
• Molecular Weight: 221.299
• Mol File: 81135-38-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 66 - 70 °C (0.002 mmHg)
• Density: 1.015±0.06 g/cm3(Predicted)
• CAS DataBase Reference: L-Valine, N-methyl-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine, N-methyl-, phenylmethyl ester(81135-38-8)
• EPA Substance Registry System: L-Valine, N-methyl-, phenylmethyl ester(81135-38-8)

Safety Data

• Hazardous Substances Data: 81135-38-8(Hazardous Substances Data)

Usage

Description

L-Valine, N-methyl-, phenylmethyl ester is a chemical compound derived from the amino acid L-valine, featuring a phenylmethyl ester group. It serves as a chiral auxiliary in organic synthesis and acts as a precursor in pharmaceutical production, playing a significant role in the synthesis of various drugs and natural products due to its unique chemical structure and reactivity.

Uses

Used in Pharmaceutical Industry:
L-Valine, N-methyl-, phenylmethyl ester is used as a chiral auxiliary for enhancing the stereochemistry of organic reactions, which is vital in the development of new pharmaceutical compounds. Its ability to produce enantiomerically pure compounds is crucial for ensuring the desired biological activity and minimizing potential side effects in drug formulations.
Used in Organic Synthesis:
L-Valine, N-methyl-, phenylmethyl ester is used as a precursor in the synthesis of various drugs and natural products. Its unique reactivity and chiral nature make it a valuable building block for creating complex organic molecules with specific stereochemistry, which is essential for the effectiveness and selectivity of pharmaceutical agents.

Upstream product

• 421-20-5 Methyl fluorosulfonate 
• 109745-93-9 N-Benzyliden-(S)-valin-benzylester 
• 13734-41-3 t-Boc-L-valine 
• 72-18-4 L-valine 
• 100-52-7 benzaldehyde 
• 16652-76-9 L-valine benzyl ester p-toluenesulfonate salt 
• 45170-31-8 Boc-N-Me-Val-OH 
• 174602-80-3 benzyl (2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]-3-methylbutanoate 
• 2016-04-8 N,N-dimethylformamide dibenzyl acetal 

Downstream Products

• 89536-99-2 benzyl (S)-2-((S)-2-((tert-butoxycarbonyl)(methyl)amino)-N,4-dimethylpentanamido)-3-methylbutanoate 
• 109745-90-6 Boc-Leu-MeVal-OBn 
• 109745-91-7 (S)-2-[((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-methyl-amino]-3-methyl-butyric acid benzyl ester 
• 89537-09-7 H-MeLeu-MeLeu-MeVal-OBzl 
• 182269-67-6 (R)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (R)-[((S)-1-benzyloxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-cyclohexyl-methyl ester 
• 182205-71-6 (S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (R)-[((S)-1-benzyloxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-cyclohexyl-methyl ester 
• 182205-72-7 (S)-3-Hydroxy-3-methyl-2-methylamino-butyric acid (1R,2R)-1-[((S)-1-benzyloxycarbonyl-2-methyl-propyl)-methyl-carbamoyl]-2-methyl-butyl ester 
• 182205-73-8 C₇₄H₁₁₀N₈O₁₄ 
• 182205-74-9 C₇₄H₁₁₀N₈O₁₄ 

Relevant articles and documents

Rational design and synthesis of unsaturated 2,5-dioxopiperazine derivatives as potential protein tyrosine kinase inhibitors

The first general method for the synthesis of a library of trifunctionalized (Z)-3-alkylidene-2,5-piperazinediones as potential protein tyrosine kinase inhibitors from commercially available amino compounds, α- keto acids and aldehydes using a novel cyclization/cleavage strategy on solid support is described.

Synthesis of cyclosporine. Part II. Synthesis of Boc-D-Ala-MeLeu-MeLeu-MeVal-OH, a part of the peptide sequence of cyclosporine, by different strategic ways and synthesis of its isomers Boc-D-Ala-MeLeu-D-MeLeu-MeVal-OH, Boc-D-Ala-Meleu-D-MeLeu-D-MeVal-OH,

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