81261-68-9

Basic information

• Product Name: 2-Pyrimidinamine, 4,6-dimethyl-N-(4-methylphenyl)-
• CAS NO: 81261-68-9
• Molecular Formula: C13H15N3
• Molecular Weight: 213.282
• Mol File: 81261-68-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-Pyrimidinamine, 4,6-dimethyl-N-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinamine, 4,6-dimethyl-N-(4-methylphenyl)-(81261-68-9)
• EPA Substance Registry System: 2-Pyrimidinamine, 4,6-dimethyl-N-(4-methylphenyl)-(81261-68-9)

Safety Data

• Hazardous Substances Data: 81261-68-9(Hazardous Substances Data)

Upstream product

• 79574-98-4 N-(4-methylphenyl)guanidinium nitrate 
• 123-54-6 acetylacetone 
• 80426-66-0 4,6-Dimethyl-1-p-tolyl-1H-pyrimidine-2-thione 

Relevant articles and documents

A novel hydride-mediated reductive rearrangement of amide: a facile synthesis of pyrimidyl and triazinyl amines

LiAlH4 and NaBH4 were found to mediate the conversion of 2-(pyrimidyl-2-ylsulfanyl)-N-arylbenzamides and 2-(triazinyl-2-ylsulfanyl)-N-arylbenzamides into pyrimidyl and triazinyl amines under notably mild conditions via a novel reductive rearrangement mechanism. These reactions invent a new route to prepare amines, which are a kind of important biologically active compounds and provide the first insight into a novel hydride-promoted reductive rearrangement of amides.

Dimroth-Type Ring Transformation of 1,4,6-Trisubstituted-2(1H)-Pyrimidinethiones with Ammonia and Primary Alkyl Amines

1,4,6-Trisubstituted-2(1H)-pyrimidinethiones (Ia-k) underwent Dimroth-type ring transformation with ammonia and prymary alkyl amines in the presence of silver perchlorate to afford 2-(N-substituted)aminopyrimidines (IIa, c, d, f, j, k) and pyrimidinium perchlorates (IIIa-c, e-j), respectively.Furthermore, pyrimidinium perchlorates (III) were converted into 2(1H)-pyrimidinones (IV) in high yields by hydrolysis with concentrated hydrochloric acid.Keywords --- Dimroth-type ring transformation reaction; ammonia; primary alkyl amines; 2-(N-substituted)aminopyrimidines; silver perchlorate; 2-(N-substituted)aminopyrimidinium perchlorates; hydrolysis; concentrated hydrochloric acid