81486-91-1 Usage
General Description
CYCLOHEXYL(PIPERAZINO)METHANONE HYDROCHLORIDE is a chemical compound that is commonly used in the pharmaceutical industry. It is a derivative of piperazine, a chemical that is often used as an antipsychotic and antiemetic agent. CYCLOHEXYL(PIPERAZINO)METHANONE HYDROCHLORIDE has been shown to have potential therapeutic effects in the treatment of various central nervous system disorders, including anxiety and depression. Its mechanism of action is believed to involve modulating the activity of certain neurotransmitters in the brain, such as dopamine and serotonin. Additionally, CYCLOHEXYL(PIPERAZINO)METHANONE HYDROCHLORIDE has been studied for its potential role in the treatment of substance abuse disorders, as well as its potential use as a drug for enhancing cognitive function and memory. Further research is needed to fully understand its pharmacological properties and potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 81486-91-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,4,8 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 81486-91:
(7*8)+(6*1)+(5*4)+(4*8)+(3*6)+(2*9)+(1*1)=151
151 % 10 = 1
So 81486-91-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H20N2O.ClH/c14-11(10-4-2-1-3-5-10)13-8-6-12-7-9-13;/h10,12H,1-9H2;1H
81486-91-1Relevant articles and documents
3-Substituted 2-phenyl-indoles: Privileged structures for medicinal chemistry
Johansson, Henrik,Jorgensen, Tanja Bogeloov,Gloriam, David E.,Braeuner-Osborne, Hans,Pedersen, Daniel Sejer
, p. 945 - 960 (2013/04/24)
Privileged structures have been used in drug discovery targeting G protein-coupled receptors (GPCR) and other protein classes for more than 20 years. Their rich activity profiles and drug-like characteristics lend themselves to increased productivity in hit identification and lead optimisation. Recently we discovered two allosteric modulators 1 and 2 for the G protein-coupled receptor GPRC6A incorporating the privileged 2-phenyl-indole scaffold, functionalised at the 3-position. In order to develop new potential GPRC6A ligands we engaged in the development of synthetic routes to provide 2-phenyl-indoles with a variety of substituents at the indole 3-position. Herein we describe the development of optimised and efficient synthetic routes to a series of new 2-phenyl-indole building blocks 3 to 9 and show that these can be used to generate a broad variety of 3-substituted 2-phenyl-indoles of interest to medicinal chemists.
