816-27-3Relevant articles and documents
HETEROCYCLIC AMIDES AS KINASE INHIBITORS FOR USE IN THE TREATMENT CANCER
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Page/Page column 82; 100, (2020/03/24)
Disclosed is a method of treating cancer in a human in need thereof, the method comprising administering to the human a RIP1 kinase inhibitor at a dose of about 50 mg to about 1600 mg. Also disclosed is a method of treating cancer in a human in need thereof, the method comprising administering to the human a RIP1 kinase inhibitor at a dose of about 50 mg to about 1600 mg, and administering to the human a PD1 antagonist thereof at a dose of about 200 mg.
INHIBITORS OF PI3 KINASE
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Page/Page column 106, (2010/01/12)
The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.
Applications of ethyl carboethoxyformimidate to heterocyclic synthesis: Preparation of condensed pyrazinones and 1,4-oxazinones
McKillop, Alexander,Chattopadhyay, Shital K.,Henderson, Alan,Avendano, Carmen
, p. 301 - 304 (2007/10/03)
Aromatic and heteroaromatic 1,2-diamines, and o-aminophenols, condense smoothly with ethyl carboethoxyformimidate to give good yields of condensed pyrazinones and 1,4-oxazinones.