816456-26-5

Basic information

• Product Name: 4-[2-(4-acetyl-3-chloro-phenoxy)-ethyl]-piperazine-1-carboxylic acid ethyl ester
• Synonyms: 4-[2-(4-acetyl-3-chloro-phenoxy)-ethyl]-piperazine-1-carboxylic acid ethyl ester
• CAS NO: 816456-26-5
• Molecular Weight: 354.834
• Mol File: 816456-26-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[2-(4-acetyl-3-chloro-phenoxy)-ethyl]-piperazine-1-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(4-acetyl-3-chloro-phenoxy)-ethyl]-piperazine-1-carboxylic acid ethyl ester(816456-26-5)
• EPA Substance Registry System: 4-[2-(4-acetyl-3-chloro-phenoxy)-ethyl]-piperazine-1-carboxylic acid ethyl ester(816456-26-5)

Safety Data

• Hazardous Substances Data: 816456-26-5(Hazardous Substances Data)

Upstream product

• 14000-66-9 1-ethoxycarbonyl-4-(2-hydroxyethyl)piperazine 
• 68301-59-7 1-(2-chloro-4-hydroxyphenyl)ethan-1-one 

Relevant articles and documents

Pyrazole derivatives as new potent and selective 20-hydroxy-5,8,11,14- eicosatetraenoic acid synthase inhibitors

Introduction of a piperazino group to the selective and potent 20-HETE synthase inhibitor 1 to obtain potential therapeutic agents with suitable water-solubility for injectable formulation is described. Improvement of the physical properties of pyrazole derivative 1, which we reported previously as a potent and selective 20-HETE synthase inhibitor (IC50 5.7 nM), is described. Introduction of a sufficient substituted-amino group on the side chain enhanced the water-solubility of 1 (0.014 mg/mL at pH 6.8). Among the products, 2-piperazinoethoxy derivatives 3e and 6b showed solubility suitable for injection and potent inhibitory activity toward 20-HETE synthase (IC 50 21.2 and 14.0 nM, respectively).