816468-38-9 Usage
Chemical structure
1-Boc-3-(4-methoxyphenylamino)-piperidine is a piperidine derivative with a Boc protecting group at the 1-position and a 4-methoxyphenylamino group at the 3-position.
Boc protecting group
The Boc (tert-butyloxycarbonyl) group is used to protect amines in organic synthesis, allowing for selective reactions at other functional groups.
4-methoxyphenylamino group
This group is a common moiety found in various pharmaceuticals and biologically active compounds.
Application
1-Boc-3-(4-methoxyphenylamino)-piperidine can be used as a building block for the synthesis of drug candidates or as a research tool in medicinal chemistry.
Organic synthesis
This compound is used in organic synthesis, which is the study of the structure, preparation, and properties of carbon compounds.
Drug development
It is utilized in the development of new drugs, which involves the design, synthesis, and testing of new chemical entities for therapeutic use.
Biological activity
The presence of the 4-methoxyphenylamino group suggests that this compound may have potential biological activity, making it a valuable starting point for the development of new pharmaceuticals.
Medicinal chemistry
As a research tool, 1-Boc-3-(4-methoxyphenylamino)-piperidine can be used to study the interactions between biological targets and potential drug molecules, contributing to the advancement of medicinal chemistry.
Synthesis
The compound can be synthesized through various chemical reactions, involving the formation of the piperidine ring and the introduction of the Boc protecting group and the 4-methoxyphenylamino group.
Selectivity
The presence of the Boc protecting group allows for selective reactions at other functional groups, which is crucial for the synthesis of complex drug molecules with specific properties and activities.
Check Digit Verification of cas no
The CAS Registry Mumber 816468-38-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,6,4,6 and 8 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 816468-38:
(8*8)+(7*1)+(6*6)+(5*4)+(4*6)+(3*8)+(2*3)+(1*8)=189
189 % 10 = 9
So 816468-38-9 is a valid CAS Registry Number.
816468-38-9Relevant articles and documents
METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS
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Paragraph 379-381, (2021/11/06)
The subject matter described herein is directed to ferroportin inhibitor compounds of Formula (I) and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.
Palladium-mediated arylation of 3-aminopiperidines and 3-aminopyrrolidines
Jean, Ludovic,Rouden, Jacques,Maddaluno, Jacques,Lasne, Marie-Claire
, p. 8893 - 8902 (2007/10/03)
This paper describes the palladium-catalyzed arylation of 1-substituted 3-aminopyrrolidines or piperidines. Palladium(0) (1-2 mol %) in conjunction with "Buchwald's ligand" [2-(dimethylamino)-2′- (dicyclohexylphosphine)biphenyll was shown to be the catalyst of choice for the coupling with aryl bromides or chlorides. When bromobenzene was used, a strong temperature effect was noticed. Whereas no reaction occurred at 100 °C, yields higher than 85% were obtained at 130 °C for each substrate. Such an effect was not observed when diphosphines were used. Whereas Xantphos and, to a lesser extent BINAP, were moderately efficient in the coupling of all diamines, the palladium-mediated arylation in the presence of monophosphines was strongly dependent on the substrate. The results suggest the participation of both nitrogens of the aminoheterocycle in the reactive intermediate. This participation could also account for the highly selective arylation of the endocyclic nitrogen of unsubstituted 3-aminopyrrolidine or piperidine. Optimal conditions were found for the arylation using 2- or 4-substituted electron-poor or enriched aryl halides.
