816468-50-5 Usage
Chemical compound
A chemical compound used in the synthesis of pharmaceuticals and organic compounds.
Piperidine derivative
It is derived from piperidine, a heterocyclic amine.
BOC protective group
Contains a tert-butoxycarbonyl (BOC) group, which serves as a protecting group for the molecule.
Trifluoromethyl-phenylamino substituent
Features a 4-trifluoromethyl-phenylamino group attached to the piperidine core.
Building block
Acts as a building block for the synthesis of various drug candidates due to its unique structure and reactivity.
Precursor
Used as a precursor in the production of various organic molecules.
Versatile compound
Its structure and reactivity make it a valuable compound in the field of organic chemistry and drug discovery.
Pharmaceutical applications
Utilized in the development of new pharmaceuticals.
Organic synthesis
Plays a role in the synthesis of organic compounds.
Drug discovery
Contributes to the identification and development of potential drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 816468-50-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,6,4,6 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 816468-50:
(8*8)+(7*1)+(6*6)+(5*4)+(4*6)+(3*8)+(2*5)+(1*0)=185
185 % 10 = 5
So 816468-50-5 is a valid CAS Registry Number.
816468-50-5Relevant articles and documents
Palladium-mediated arylation of 3-aminopiperidines and 3-aminopyrrolidines
Jean, Ludovic,Rouden, Jacques,Maddaluno, Jacques,Lasne, Marie-Claire
, p. 8893 - 8902 (2007/10/03)
This paper describes the palladium-catalyzed arylation of 1-substituted 3-aminopyrrolidines or piperidines. Palladium(0) (1-2 mol %) in conjunction with "Buchwald's ligand" [2-(dimethylamino)-2′- (dicyclohexylphosphine)biphenyll was shown to be the catalyst of choice for the coupling with aryl bromides or chlorides. When bromobenzene was used, a strong temperature effect was noticed. Whereas no reaction occurred at 100 °C, yields higher than 85% were obtained at 130 °C for each substrate. Such an effect was not observed when diphosphines were used. Whereas Xantphos and, to a lesser extent BINAP, were moderately efficient in the coupling of all diamines, the palladium-mediated arylation in the presence of monophosphines was strongly dependent on the substrate. The results suggest the participation of both nitrogens of the aminoheterocycle in the reactive intermediate. This participation could also account for the highly selective arylation of the endocyclic nitrogen of unsubstituted 3-aminopyrrolidine or piperidine. Optimal conditions were found for the arylation using 2- or 4-substituted electron-poor or enriched aryl halides.
