816468-54-9 Usage
Piperidine derivative
A compound based on the piperidine ring structure This indicates that the compound is derived from the basic structure of a piperidine ring, which is a six-membered ring containing one nitrogen atom.
BOC protecting group
tert-butyloxycarbonyl group attached to the nitrogen atom This refers to the presence of a protective group that shields the nitrogen atom from unwanted reactions, allowing for selective manipulation of the compound during synthesis.
Common use as an intermediate
In the synthesis of pharmaceuticals and agrochemicals This highlights the compound's role as a building block in the production of various drugs and chemicals used in agriculture.
Selective manipulation
Enabled by the BOC protecting group during chemical reactions This property allows chemists to control the reactivity of the compound, making it easier to synthesize more complex molecules.
Potential biological activities
Of interest for further research and development This suggests that the compound may have biological effects that could be useful in the development of new drugs or therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 816468-54-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,6,4,6 and 8 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 816468-54:
(8*8)+(7*1)+(6*6)+(5*4)+(4*6)+(3*8)+(2*5)+(1*4)=189
189 % 10 = 9
So 816468-54-9 is a valid CAS Registry Number.
816468-54-9Relevant articles and documents
Palladium-mediated arylation of 3-aminopiperidines and 3-aminopyrrolidines
Jean, Ludovic,Rouden, Jacques,Maddaluno, Jacques,Lasne, Marie-Claire
, p. 8893 - 8902 (2007/10/03)
This paper describes the palladium-catalyzed arylation of 1-substituted 3-aminopyrrolidines or piperidines. Palladium(0) (1-2 mol %) in conjunction with "Buchwald's ligand" [2-(dimethylamino)-2′- (dicyclohexylphosphine)biphenyll was shown to be the catalyst of choice for the coupling with aryl bromides or chlorides. When bromobenzene was used, a strong temperature effect was noticed. Whereas no reaction occurred at 100 °C, yields higher than 85% were obtained at 130 °C for each substrate. Such an effect was not observed when diphosphines were used. Whereas Xantphos and, to a lesser extent BINAP, were moderately efficient in the coupling of all diamines, the palladium-mediated arylation in the presence of monophosphines was strongly dependent on the substrate. The results suggest the participation of both nitrogens of the aminoheterocycle in the reactive intermediate. This participation could also account for the highly selective arylation of the endocyclic nitrogen of unsubstituted 3-aminopyrrolidine or piperidine. Optimal conditions were found for the arylation using 2- or 4-substituted electron-poor or enriched aryl halides.
