81867-09-6

Basic information

• Product Name: Benzenepentanoic acid, a-oxo-, ethyl ester
• CAS NO: 81867-09-6
• Molecular Formula: C13H16O3
• Molecular Weight: 220.268
• Mol File: 81867-09-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenepentanoic acid, a-oxo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepentanoic acid, a-oxo-, ethyl ester(81867-09-6)
• EPA Substance Registry System: Benzenepentanoic acid, a-oxo-, ethyl ester(81867-09-6)

Safety Data

• Hazardous Substances Data: 81867-09-6(Hazardous Substances Data)

Upstream product

• 34795-56-7 2-cyano-5-phenyl-pentanoic acid ethyl ester 
• 637-59-2 1-Bromo-3-phenylpropane 
• 1462-75-5 3-phenylpropylmagnesium bromide 
• 95-92-1 oxalic acid diethyl ester 
• 64-17-5 ethanol 
• 88768-11-0 2-oxo-5-phenylpentanoic acid 

Downstream Products

• 27356-88-3 ethyl 2-methylene-5-phenylpentanoate 
• 62777-25-7 (S)-2-amino-4-phenylvaleric acid 
• 871514-43-1 ethyl (2S,3S,4R)-5-benzyloxy-3,4-(dimethylmethylenedioxy)-2-hydroxy-3-methoxycarbonyl-2-(3-phenylpropyl)pentanoate 
• 871514-40-8 ethyl (2R,3S,4R)-5-benzyloxy-3,4-(dimethylmethylenedioxy)-2-hydroxy-3-methoxycarbonyl-2-(3-phenylpropyl)pentanoate 
• 871514-42-0 ethyl (3S,4S,8R)-8-(benzyloxymethyl)-6,6-dimethyl-1-oxo-3-(3-phenylpropyl)-2,5,7-trioxaspiro[3.4]octane-3-carboxylate 
• 871514-39-5 ethyl (3R,4S,8R)-8-(benzyloxymethyl)-6,6-dimethyl-1-oxo-3-(3-phenylpropyl)-2,5,7-trioxaspiro[3.4]octane-3-carboxylate 
• 890414-71-8 (3E)-4-[4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]but-3-en-2-one 
• 890414-73-0 4-[4-(hydroxymethyl)-5-(2-phenylethyl)-1,3-thiazol-2-yl]-1-[(3-phenylpropyl)thio]butan-2-one 
• 890414-86-5 (E)-4-(4-Hydroxymethyl-5-phenethyl-thiazol-2-yl)-1-(3-phenyl-propylsulfanyl)-but-3-en-2-one 
• 890414-84-3 4-(tert-butyl-dimethyl-silanyloxymethyl)-5-phenethyl-thiazole-2-carbaldehyde 
• 890414-82-1 4-(tert-butyl-dimethyl-silanyloxymethyl)-5-phenethyl-thiazol-2-ylamine 
• 890414-69-4 2-bromo-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-5-(2-phenylethyl)-1,3-thiazole 
• 890414-67-2 ethyl 2-amino-5-(2-phenylethyl)-1,3-thiazole-4-carboxylate 
• 890414-80-9 (2-amino-5-phenethyl-thiazol-4-yl)-methanol 

Relevant articles and documents

Switchable C-H Functionalization of N-Tosyl Acrylamides with Acryloylsilanes

A controllable Rh-catalyzed protocol to access alkylation and alkenylation-annulation of N-tosyl acrylamide with acryloyl silane is reported. In contrast to the directing group or catalyst-dependent divergent sp2 C-H alkylation/alkenylation, the intrinsic property of acryloylsilane allows the switchable reaction manifold, thereby affording either alkylation or annulation products with slight modification of the reaction conditions.

Continuous flow based catch and release protocol for the synthesis of α-ketoesters

Using a combination of commercially available mesofluidic flow equipment and tubes packed with immobilised reagents and scavengers, a new synthesis of a-ketoesters is reported.

Design, synthesis and evaluation of trisubstituted thiazoles targeting Plasmodium falciparum cysteine proteases

The Plasmodium falciparum cysteine proteases, falcipains, have been established as novel targets for antimalarial drug design. Using the de novo design approach, several trisubstituted thiazole analogs were generated as potential inhibitors of these enzymes. A general and convenient synthetic approach for these novel trisubstituted thiazoles is reported here. Substituents at the 4th and 5th positions of the target thiazoles were introduced by a Hantzsch reaction, and the chain at the second position was extended through a Sandmeyer reaction, formylation, and Wittig olefination. In vitro enzyme inhibition studies have identified three inhibitors (14, 16, 23) of the falcipains with one (14) showing dual activity against both falcipain-2 and falcipain-3 and IC50 values of 6.6 and 29.4 μM, respectively. Birkhaeuser Boston 2005.