81875-18-5

Basic information

• Product Name: 2-Methyl-2-(3-oxo-2-phenylsulfanyl-cyclopentyl)-malonic acid dimethyl ester
• CAS NO: 81875-18-5
• Molecular Weight: 336.409
• Mol File: 81875-18-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Methyl-2-(3-oxo-2-phenylsulfanyl-cyclopentyl)-malonic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-2-(3-oxo-2-phenylsulfanyl-cyclopentyl)-malonic acid dimethyl ester(81875-18-5)
• EPA Substance Registry System: 2-Methyl-2-(3-oxo-2-phenylsulfanyl-cyclopentyl)-malonic acid dimethyl ester(81875-18-5)

Safety Data

• Hazardous Substances Data: 81875-18-5(Hazardous Substances Data)

Upstream product

• 609-02-9 methyl-malonic acid dimethylester 
• 34780-08-0 2-(phenylthio)cyclopent-2-en-1-one 

Downstream Products

• 81875-25-4 2-(3-Methoxy-2-phenylsulfanyl-cyclopent-2-enyl)-2-methyl-malonic acid dimethyl ester 

Relevant articles and documents

Michael Reactions in Aprotic Media. An Effective Method of Construction of α,α,β-Trisubstituted Ketones and Application to Natural Product Synthesis

By proper selection of the reaction conditions, 1,4-additions of malonate and propionate anions to 2-(phenylthio)-2-cyclopentenone were accomplished.Subsequent trapping of the intermediate enolates with an electrophile in the aprotic media afforded α,α,β-trisubstituted ketones regiospecifically.The effects of the counterion, solvent, and temperature were examined.An application of this method to the formal synthesis of the pseudoguaianolides (+/-)-aromatin and (+/-)-confertin is described.