81989-95-9

Basic information

• Product Name: CYSTATIN
• Synonyms: CYSTATIN;CYSTEINE PROTEASE INHIBITOR;CYSTATIN, EGG WHITE;OVOCYSTATIN;Cystatin from chicken egg white;cystatin from egg white;cystatin from hen egg white;cystatin solution from hen egg white
• CAS NO: 81989-95-9
• Molecular Formula: C18H14N4O
• Molecular Weight: 302.32996
• Mol File: 81989-95-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: 2-8°C
• Solubility: 0.1 M phosphate pH 6.5: 20 mg/L, very slightly hazy, colorl
• CAS DataBase Reference: CYSTATIN(CAS DataBase Reference)
• NIST Chemistry Reference: CYSTATIN(81989-95-9)
• EPA Substance Registry System: CYSTATIN(81989-95-9)

Safety Data

• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 81989-95-9(Hazardous Substances Data)

Usage

Description

Cystatin is a group of endogenous proteinase inhibitors that are involved in the regulation of intracellular and extracellular proteolysis. It is a small protein that belongs to the family of cysteine protease inhibitors and is characterized by its ability to inhibit the activity of cysteine proteases, such as papain and dipeptidyl peptidase III. Cystatin is found in various body fluids and tissues, including blood, cerebrospinal fluid, and saliva, and plays a crucial role in maintaining the balance between proteolysis and antiproteolysis in the body.

Uses

Used in Pharmaceutical Industry:
Cystatin is used as a therapeutic agent for the treatment of various diseases and conditions that involve abnormal proteolysis, such as cancer, autoimmune diseases, and neurodegenerative disorders. Its ability to inhibit cysteine proteases makes it a potential candidate for the development of drugs that can modulate the activity of these enzymes and prevent the degradation of proteins and tissues.
Used in Research Applications:
Cystatin is used as a research tool for studying the function and regulation of cysteine proteases in various biological processes. It is employed in biochemical assays, enzyme-linked immunosorbent assays (ELISA), and other laboratory techniques to investigate the role of these enzymes in cellular processes and disease mechanisms.
Used in Diagnostic Applications:
Cystatin can be used as a biomarker for the diagnosis and monitoring of certain diseases and conditions. Its levels in body fluids, such as blood and cerebrospinal fluid, can provide valuable information about the presence and progression of diseases that involve abnormal proteolysis, such as cancer and neurodegenerative disorders.
Inhibitor of Cysteine Proteases:
Cystatin is used as an inhibitor of cysteine proteases, including papain and dipeptidyl peptidase III, for the study of the mechanism of inhibition. An effective concentration equimolar with protease has been determined, and a docking model has been proposed to explain the mechanism of inhibition of papain by cystatin. This information can be useful for the development of new drugs and therapies that target these enzymes and their associated diseases.