820223-49-2

Basic information

• Product Name: (R)-{[4-(4-trifluoromthoxyphenyl)thien-2-yl]carboxamido}(phenyl)propanoic acid
• Synonyms: (R)-{[4-(4-trifluoromthoxyphenyl)thien-2-yl]carboxamido}(phenyl)propanoic acid
• CAS NO: 820223-49-2
• Molecular Weight: 435.424
• Mol File: 820223-49-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-{[4-(4-trifluoromthoxyphenyl)thien-2-yl]carboxamido}(phenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-{[4-(4-trifluoromthoxyphenyl)thien-2-yl]carboxamido}(phenyl)propanoic acid(820223-49-2)
• EPA Substance Registry System: (R)-{[4-(4-trifluoromthoxyphenyl)thien-2-yl]carboxamido}(phenyl)propanoic acid(820223-49-2)

Safety Data

• Hazardous Substances Data: 820223-49-2(Hazardous Substances Data)

Upstream product

• 666721-04-6 4-[4-(trifluoromnethoxy)phenyl]thiophene-2-carbonyl chloride 
• 614-19-7 (R)-3-phenyl-3-aminopropionic acid 
• 16694-18-1 4-bromo-thiophene-2-carboxylic acid 
• 18791-75-8 4-Bromothiophen-2-aldehyde 
• 666721-06-8 4-[4-(trifluoromethoxy)phenyl]thiophene-2-carboxylic acid 

Relevant articles and documents

Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors

A new class of MMP-12 inhibitors was discovered and optimized using structure-based drug design methods. Modeling studies using a known MMP-12 crystal structure identified a new interaction mode for these new MMP-12 inhibitors. Further optimization resulted in the discovery of a compound displaying nanomolar activity against MMP-12 and which was co-crystallized with MMP-12.