82225-32-9

Basic information

• Product Name: Propargyl 4-bromobenzamide
• Synonyms: 4-Bromo-N-(prop-2-yn-1-yl)benzamide;Propargyl 4-bromobenzamide;4-Bromo-N-(prop-2-ynyl)benzamide
• CAS NO: 82225-32-9
• Molecular Formula: C10H8BrNO
• Molecular Weight: 238.08
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 82225-32-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 363.8 °C at 760 mmHg
• Flash Point: 173.8 °C
• Appearance: /
• Density: 1.462 g/cm³
• Vapor Pressure: 1.75E-05mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: Propargyl 4-bromobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: Propargyl 4-bromobenzamide(82225-32-9)
• EPA Substance Registry System: Propargyl 4-bromobenzamide(82225-32-9)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 82225-32-9(Hazardous Substances Data)

Usage

General Description

Propargyl 4-bromobenzamide is a chemical compound with the molecular formula C9H6BrNO. It is a derivative of benzamide and contains a propargyl group and a bromine atom. Propargyl 4-bromobenzamide is commonly used in organic synthesis and medicinal chemistry research. It is known to exhibit activity as a histone deacetylase (HDAC) inhibitor, which can potentially be useful in the treatment of various diseases including cancer and neurodegenerative disorders. Additionally, propargyl 4-bromobenzamide may have other bioactive properties and is under investigation for its potential pharmacological applications.

InChI:InChI=1/C10H8BrNO/c1-2-7-12-10(13)8-3-5-9(11)6-4-8/h1,3-6H,7H2,(H,12,13)

Upstream product

• 586-75-4 4-chlorobenzoyl chloride 
• 2450-71-7 Propargylamine 
• 589-17-3 p-bromobenzyl chloride 
• 586-76-5 4-Bromobenzoic acid 

Downstream Products

• 1582306-78-2 (E)-2-(3-bromophenyl)-5-(iodomethylene)-4,5-dihydrooxazole 
• 1206983-20-1 2-(3-bromophenyl)oxazole-5-carbaldehyde 

Relevant articles and documents

Fluorocyclization of Allyl Alcohols and Amines to Access 3-Functionalized Oxetanes and Azetidines

An efficient method to prepare 3-functionalized oxetanes and azetidines has been realized by fluorocyclization of readily available 2-azidoallyl/2-alkoxyallyl alcohols and amines. Notably, this is the first example applying the fluorocyclization strategy to construct four-membered heterocycles. The pendant electron-donating group (-N3 or -OR) plays a crucial role in polarizing the C= C double bond and facilitating the cyclization process, as verified by DFT and experimental studies.

InCl3-catalyzed 5- exo-dig cyclization/1,6-conjugate addition of N -propargylamides with p -QMs to construct oxazole derivatives

An InCl3-catalyzed atom-economic intramolecular 5-exo-dig cyclization/1,6-conjugate addition/aromatization of N-propargylamides with p-QMs to produce oxazoles tethering diarylmethane has been successfully developed. InCl3 not only se

Fluorocyclization of N-Propargylamides to Oxazoles by Electrochemically Generated ArIF2

A sustainable synthesis of 5-fluoromethyl-2-oxazoles by use of electrochemistry has been demonstrated. Hypervalent ArIF2 is generated by direct electrochemical oxidation of iodoarene ArI in Et3N·5HF and mediates the fluorocyclization