823-37-0 Usage
Description
1-methyl-2-nitro-pyrrole is a chemical compound characterized by the molecular formula C5H6N2O2. It is a pale yellow solid that features a nitro group and a pyrrole ring as its functional groups. 1-methyl-2-nitro-pyrrole is recognized for its versatility in organic synthesis, primarily due to the presence of the nitro group, which enables a broad spectrum of chemical reactions.
Uses
Used in Pharmaceutical and Agrochemical Industries:
1-methyl-2-nitro-pyrrole serves as a crucial building block in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and functional groups contribute to the development of new and effective compounds for medical and agricultural applications.
Used in Dye and Pigment Production:
In the dye and pigment industry, 1-methyl-2-nitro-pyrrole is utilized for the production of a range of dyes and pigments. Its chemical properties allow for the creation of vibrant and stable colorants that are used in various applications, including textiles, plastics, and printing inks.
Used in Organic Synthesis:
As a versatile intermediate in organic synthesis, 1-methyl-2-nitro-pyrrole is employed in a wide range of chemical reactions. Its nitro group facilitates various synthetic pathways, making it an indispensable component in the preparation of complex organic molecules.
Safety Considerations:
It is important to handle 1-methyl-2-nitro-pyrrole with care, as it may pose health risks if ingested or inhaled. Adequate safety measures should be taken during its production, storage, and use to minimize potential hazards.
Check Digit Verification of cas no
The CAS Registry Mumber 823-37-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,2 and 3 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 823-37:
(5*8)+(4*2)+(3*3)+(2*3)+(1*7)=70
70 % 10 = 0
So 823-37-0 is a valid CAS Registry Number.
InChI:InChI=1/C5H6N2O2/c1-6-4-2-3-5(6)7(8)9/h2-4H,1H3
823-37-0Relevant articles and documents
ALKYLATION ORIENTATION RULES IN CONJUGATE ADDITION OF GRIGNARD REAGENTS TO NITROPYRROLE AND NITROTHIOPHENE SYSTEMS
Ballini, Roberto,Bartoli, Giuseppe,Bosco, Marcella,Dalpozzo, Renato,Marcantoni, Enrico
, p. 6435 - 6440 (2007/10/02)
Conjugate addition of various Grignard reagents to 1-alkyl-2-nitropyrroles and to 2-nitrothiophene has been investigated. 1-Alkyl-2-nitropyrroles undergo alkylation at 3 and 5 positions with prevalence of the latter isomer.On the contrary, in the 2-nitrothiophene system, formation of the 3-isomer prevails.In both systems, a bulkier Grignard reagent favours the 5-isomer formation.This trend can be reversed increasing steric hindrance exerted by the 1-substituent of 2-nitropyrrole. 1-(Tri-isopropylsilyl)-3-nitropyrrole and 3-nitrothiophene give exclusively the 2-isomer.This reaction allows 2-alkyl-3-nitrothiophenes and pyrroles to be synthesized with a one-pot procedure instead of the classical multi stage reaction.
Nucleophilic Aromatic Substitution in the Pyrrole Ring: Leaving Group Effect
Annulli, Alessandro,Mencarelli, Paolo,Stegel, Franco
, p. 4065 - 4067 (2007/10/02)
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PREPARATIVE ASPECTS OF THE NITRATION OF 1-METHYLPYRROLE DERIVATIVES. 13C NMR OF SOME NITROPYRROLES.
Grehn
, p. 67 - 77 (2007/10/04)
The nitration of 1-methylpyrrole and 1,2-dimethylpyrrole was studied and the products were characterized. It was found that the nitration of ethyl 1-methylpyrrole-2-carboxylate depends on the reaction conditions. **1**3C parameters have been determined for several 1-methyl substituted pyrrole- and nitropyrrole derivatives and the relationship between the observed and predicted **1**3C shifts for aromatic carbons is briefly discussed. It has been found that the determination of the direct **1**3C-**1H coupling constants in the pyrrole ring constitutes a useful tool for distinguishing alpha - and beta -positions.
