82310-97-2

Basic information

• Product Name: (S)-2-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID
• Synonyms: L-(+)-P-METHOXYHOMOPHENYLALANINE;(S)-2-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID;4-Methoxyhomophenyl-L-alanine;4-Methoxy-D-homophenylalanine
• CAS NO: 82310-97-2
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.24
• Mol File: 82310-97-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 261-263 °C(Solv: ethanol, 70% (64-17-5))
• Boiling Point: 366.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.175±0.06 g/cm3(Predicted)
• PKA: 2.28±0.10(Predicted)
• CAS DataBase Reference: (S)-2-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID(82310-97-2)
• EPA Substance Registry System: (S)-2-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID(82310-97-2)

Safety Data

• Hazardous Substances Data: 82310-97-2(Hazardous Substances Data)

Usage

General Description

(S)-2-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID, also known as L-Phenylglycine, is a chemical compound with the molecular formula C10H13NO3. It is an amino acid derivative that contains a phenyl group and a carboxylic acid group. (S)-2-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID is often used in the production of pharmaceuticals and can also be used as a chiral building block in organic synthesis. It is a white crystalline powder that is soluble in water and has a slightly sweet taste. L-Phenylglycine has potential applications in the medical, agricultural, and manufacturing industries.

Upstream product

• 20401-88-1 3-(4-methoxyphenyl)propional 
• 82267-44-5 DL-2-acetamido-4-(p-methoxyohenyl)butanoic acid 
• 14425-64-0 4-methoxyphenethyl bromide 
• 702-23-8 2-(4-Methoxyphenyl)ethanol 
• 82267-42-3 <2-(p-methoxyphenyl)ethyl>(acetamido)malonic acid 
• 82267-39-8 diethyl<2-(p-methoxyphenyl)ethyl>(acetamido)malonate 
• 22442-48-4 3-(4-methoxyphenyl)propionitrile 
• 25413-27-8 3-(4-methoxy-phenyl)propionamide 
• 90877-70-6 ethyl 2-acetamido-2-cyanoacetate 
• 112741-55-6 (3S,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-<2'-oxo-2'-(4-methoxyphenyl)ethyl>-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 171077-29-5 -2-<(benzyloxycarbonyl)amino>-4-(4-methoxyphenyl)-3-butenoic acid 
• 212010-24-7 (αS,1S)-α-[N-(1-methyl)benzyl]-β-[4'-(methoxy)benzoyl]alanine 
• 346722-47-2 (S)-2-((R)-1-Hydroxymethyl-propylamino)-4-(4-methoxy-phenyl)-butyric acid 
• 20972-37-6 (E)-4-(4-methoxyphenyl)-4-oxo-2-butenoic acid 

Downstream Products

• 87423-12-9 Boc-L-Ala-L-Hmb-L-Amb-OH 

Relevant articles and documents

METHOD FOR PREPARING AROMATIC AMINO ACID DERIVATIVE

The present invention provides methods of efficiently producing various optically active aromatic amino acid derivatives by reacting, using an additive, a specific ester compound with an aromatic halide and zinc in the presence of a catalyst. The present invention also provides amino acid derivatives that can be produced by the methods.

Changing the selectivity profile–from substrate analog inhibitors of thrombin and factor Xa to potent matriptase inhibitors

The type II transmembrane serine protease matriptase is a potential target for anticancer therapy and might be involved in cartilage degradation in osteoarthritis or inflammatory skin disorders. Starting from previously described nonspecific thrombin and factor Xa inhibitors we have prepared new noncovalent substrate-analogs with superior potency against matriptase. The most suitable compound 35 (H-d-hTyr-Ala-4-amidinobenzylamide) binds to matriptase with an inhibition constant of 26 nM and has more than 10-fold reduced activity against thrombin and factor Xa. The crystal structure of inhibitor 35 was determined in the surrogate protease trypsin, the obtained complex was used to model the binding mode of inhibitor 35 in the active site of matriptase. The methylene insertion in d-hTyr and d-hPhe increases the flexibility of the P3 side chain compared to their d-Phe analogs, which enables an improved binding of these inhibitors in the well-defined S3/4 pocket of matriptase. Inhibitor 35 can be used for further biochemical studies with matriptase.

A novel β-amino acid in cytotoxic peptides from the cyanobacterium Tychonema sp.

The cyclic dodecapeptides tychonamide A (1) and B (2) isolated from the methanolic extract of the cyanobacterium Tychonema sp. contain the novel β-amino acid 3-amino-2,5,7-trihydroxy-8-phenyloctanoic acid (Atpoa). Compounds 1 and 2 have cytotoxic activity