82318-22-7

Basic information

• Product Name: diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>octylamino>benzoyl>-L-glutamate
• Synonyms: diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>octylamino>benzoyl>-L-glutamate
• CAS NO: 82318-22-7
• Molecular Weight: 608.741
• Mol File: 82318-22-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>octylamino>benzoyl>-L-glutamate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>octylamino>benzoyl>-L-glutamate(82318-22-7)
• EPA Substance Registry System: diethyl N-<4-<<(2,4-diamino-6-pteridinyl)methyl>octylamino>benzoyl>-L-glutamate(82318-22-7)

Safety Data

• Hazardous Substances Data: 82318-22-7(Hazardous Substances Data)

Upstream product

• 16450-41-2 L-glutamic acid diethyl ester 
• 82318-19-2 (S)-2-{4-[Octyl-(toluene-4-sulfonyl)-amino]-benzoylamino}-pentanedioic acid diethyl ester 
• 52853-40-4 6-bromomethyl-2,4-diaminopteridine hydrobromide 
• 82318-20-5 diethyl N-<4-(octylamino)benzoyl>-L-glutamate 

Downstream Products

• 82318-24-9 N-<4-<<(2,4-diamino-6-pteridinyl)methyl>octylamino>benzoyl>-L-glutamic acid 

Relevant articles and documents

10-Propargylaminopterin and Alkyl Homologues of Methotrexate as Inhibitors of Folate Metabolism

Reported antifolate activity against leukemia L1210 by N-propargylamino>benzoyl>-L-glutamic acid through potent inhibition of thymidylate synthase (EC 2.1.1.45) prompted us to include the propargyl group in a