824-98-6

Basic information

• Product Name: 3-Methoxybenzyl chloride
• Synonyms: (3-Methoxyphenyl)methyl chloride;a-Chloro-m-methoxytoluene;1-Methoxy-3-(chloromethyl)benzene;3-Methoxy-1-(chloromethyl)benzene;3-Methoxybenzyl chloride,97%;3-Methoxybenzyl chlo;3-Methoxybenzyl chloride, 97% 5GR;1-(Chloromethyl)-3-methoxybenzene, 3-(Chloromethyl)phenyl methyl ether, 3-(Chloromethyl)anisole
• CAS NO: 824-98-6
• Molecular Formula: C₈H₉ClO
• Molecular Weight: 156.61
• EINECS: 212-541-1
• Product Categories: Chemical intermediate for Sarpogrelate hydrochloride
• Mol File: 824-98-6.mol
• Article Data: 32

Chemical Properties

• Melting Point: 101.67°C
• Boiling Point: 124 °C13 mm Hg(lit.)
• Flash Point: 215 °F
• Appearance: clear colorless to light yellow liquid
• Density: 1.078 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0284mmHg at 25°C
• Refractive Index: n20/D 1.544(lit.)
• Storage Temp.: Store at?0-5°C
• Sensitive: Moisture Sensitive
• BRN: 636684
• CAS DataBase Reference: 3-Methoxybenzyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxybenzyl chloride(824-98-6)
• EPA Substance Registry System: 3-Methoxybenzyl chloride(824-98-6)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 1
• F: 19-21
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 824-98-6(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to light yellow liquid

Uses

3-Methoxybenzyl chloride was used to alkylate 8-benzyloxy-2(1H)-quinolinone in the presence of DMF and NaH. It was also used in the synthesis of diarylmethanes via in situ organozinc-mediated, palladium-catalyzed cross-coupling between benzyl and aryl halide.

InChI:InChI=1/C8H9ClO/c1-10-8-4-2-3-7(5-8)6-9/h2-5H,6H2,1H3

Upstream product

• 6971-51-3 3-methoxybenzyl alcohol 
• 59276-28-7 m-anisaldehyde dimethyl acetal 
• 51755-56-7 (3-methoxybenzyl)trimethylsilane 
• 1801-77-0 oxovanadium(V) ethoxydichloride 
• 1515-82-8 1-methoxy-3-(methoxymethyl)benzene 
• 100-83-4 meta-hydroxybenzaldehyde 
• 77-78-1 dimethyl sulfate 
• 191402-51-4 5-(1-Chloro-2,2,2-trifluoro-ethyl)-2-methoxy-benzonitrile 
• 65108-13-6 C₈H₉O⁽¹⁺⁾ 
• 7782-50-5 chlorine 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 42051-04-7 3-methoxybenzyl tosylate 
• 421-50-1 1,1,1-trifluoro-2-propanone 
• 66192-25-4 2-bromo-5-methoxybenzyl chloride 

Downstream Products

• 109932-63-0 2-(3-methoxy-benzyl)-2,3,4,9-tetrahydro-1H-β-carboline 
• 92902-76-6 bis-(2-chloro ethyl)-(3-methoxy-benzyl)-amine 
• 20056-57-9 1-methoxy-3-pentylbenzene 
• 19924-43-7 3-methoxyphenylacetonitrile 
• 1798-09-0 m-methoxyphenylacetic acid 
• 148234-87-1 bis-(3-methoxy-benzyl)-methyl-amine 
• 36707-27-4 1,2-bis(3-methoxyphenyl)ethane 
• 55142-92-2 5-(3-methoxy-benzyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine 
• 66325-64-2 3'-methoxybenzylcyclohexanol 
• 35107-77-8 3-methoxybenzyldimethylsilane 
• 189812-98-4 [4-(3-Methoxy-phenyl)-but-1-ynyl]-trimethyl-silane 
• 65354-70-3 2-(m-Methoxyphenyl)isopropylidenecyclopropane 
• 65354-64-5 2-(m-Methoxyphenyl)-3,3-dimethylmethylenecyclopropane 
• 155820-00-1 1-methoxy-3-tert-pentylbenzene 

Relevant articles and documents

Total synthesis of enhygrolide A and analogs

The total synthesis of enhygrolide A, a γ-alkylidene butenolide natural product which exhibits antibacterial activities, is reported. The synthetic route features several key transformations, including a copper mediated Sonogashira/oxacyclization 5-exo-dig process to generate the alkylidene butenolide system and a Suzuki cross-coupling to introduce the benzylic unit. The methodology employed for this total synthesis represents a sufficiently flexible route to allow the synthesis of numerous analogs of these enhygrolides.

Ionic-Liquid-Supported 1,3-Dimethylimidazolidin-2-one: Application as a Reusable Halogenation Reagent

We describe the synthesis of ionic-liquid-supported 1,3-dimethylimidazolidin-2-one, together with the halogenation of alcohols in a reaction system in which this reagent is combined with oxalyl chloride. A new method was established that does not require additives such as bases, and which permits the ready isolation and purification of the product. Good conversions were obtained, and good reusability of the reagent was observed.

2-OXO-3,4-DIHYDROPYRIDINE-5-CARBOXYLATES AND THEIR USE

The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.