825-04-7

Basic information

• Product Name: Cyclohexanecarboxylic acid, 1-methyl-, methyl ester
• Synonyms: Cyclohexane-1-carboxylic acid, 1-methyl, methyl ester
• CAS NO: 825-04-7
• Molecular Formula: C₉H₁₆O₂
• Molecular Weight: 156.225
• Mol File: 825-04-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 182.301 °C at 760 mmHg
• Flash Point: 61.427 °C
• Density: 0.961 g/cm³
• CAS DataBase Reference: Cyclohexanecarboxylic acid, 1-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 1-methyl-, methyl ester(825-04-7)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 1-methyl-, methyl ester(825-04-7)

Safety Data

• Hazardous Substances Data: 825-04-7(Hazardous Substances Data)

Usage

General Description

Cyclohexanecarboxylic acid, 1-methyl-, methyl ester, also known as 1-methylcyclohexanecarboxylic acid methyl ester, is a chemical compound with the formula C9H16O2. It is a colorless liquid that is commonly used as a flavoring agent and fragrance ingredient. Cyclohexanecarboxylic acid, 1-methyl-, methyl ester is often found in essential oils and is known for its sweet, citrus-like aroma. It is also used as a solvent in various industrial applications. Additionally, it has been studied for its potential use in pharmaceuticals and as a precursor in organic synthesis. Overall, cyclohexanecarboxylic acid, 1-methyl-, methyl ester has various commercial and industrial uses due to its pleasant aroma and versatile chemical properties.

Upstream product

• 67-56-1 methanol 
• 14064-13-2 (1-methylcyclohexyl)methanol 
• 4630-82-4 methyl cyclohexylcarboxylate 
• 74-88-4 methyl iodide 
• 1123-25-7 1-methyl-1-cyclohexanecarboxylic acid 
• 61985-23-7 methyl 1-imidazolecarboxylate 
• 56078-05-8 Methyl-1-(2',2'-dimethoxyethyl)-cyclohexan-1-carboxylat 
• 41487-74-5 2,2-Dibromospiro<3,5>nonan-1-on 
• 29800-45-1 spiro[3.5]nonan-1-one 
• 41487-75-6 Methyl-1-(2',2'-dibrom-ethyl)-cyclohexan-1-carboxylat 
• 111-24-0 1,5-dibromo-pentane 
• 823-76-7 Cyclohexyl methyl ketone 
• 125259-09-8 1-Methyl-cyclohexanecarboxylic acid (E)-1-methyl-3-phenyl-allyl ester 
• 98-89-5 Cyclohexanecarboxylic acid 

Downstream Products

• 50993-21-0 1-methyl-N-phenylcyclohexane-1-carboxamide 
• 1123-25-7 1-methyl-1-cyclohexanecarboxylic acid 
• 27331-02-8 2-(1-methyl-cyclohexyl)-propan-2-ol 
• 98627-38-4 1-(1-methylcyclohexyl) cyclopentanol 
• 95882-32-9 3-(1-methylcyclohexyl)-3-oxopropanenitrile 
• 1337931-74-4 3-(1-methylcyclohexyl)-1-(p-tolyl)-1H-pyrazol-5-amine 
• 56294-19-0 methyl 1-methyl-3-oxocyclohexane-1-carboxylate 
• 37480-41-4 methyl 1-methyl-4-oxo-1-cyclohexanecarboxylate 
• 1429896-59-2 1-methyl-N-(quinolin-8-yl)cyclohexane-1-carboxamide 
• 2890-61-1 1-methyl-1-cyclohexancarboxylic acid chloride 
• 1360568-84-8 (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-((1-methylcyclohexyl)methoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol 
• 1360568-83-7 4-bromo-1-chloro-2-(4-((1-methylcyclohexyl)methoxy)benzyl)benzene 
• 14064-12-1 (1-methylcyclohexyl)methyl-4-methylbenzenesulfonate 
• 91138-78-2 1-(α-Chlor-isopropyl)-1-methyl-cyclohexan 

Relevant articles and documents

Nickel-catalysed direct alkylation of thiophenes via double C(sp3)-H/C(sp2)-H bond cleavage: The importance of KH2PO4

A Ni-catalyzed oxidative C-H/C-H cross-dehydrogenative coupling (CDC) reaction was developed for constructing various highly functionalized alkyl (aryl)-substituted thiophenes. This method employs thiophenes and aliphatic (aromatic) amides that contain an 8-aminoquinoline as a removable directing group in the presence of a silver oxidant. The approach enables the facile one-step synthesis of substituted thiophenes with high functional group compatibility via double C-H bond cleavage without affecting C-Br and C-I bonds. DFT calculations verify the importance of KH2PO4 as an additive for promoting C-H bond cleavage and support the involvement of a Ni(iii) species in the reaction.

CYCLOALKYL METHOXYBENZYL PHENYL PYRAN DERIVATIVES AS SODIUM DEPENDENT GLUCOSE CO TRANSPORTER (SGLT2) INHIBITORS

The invention relates to the cycloalkyl methoxybenzyl phenyl pyran derivatives as Sodium dependent glucose co transporter (SGLT) inhibitors, particularly SGLT2 and method of treating diseases, conditions and/or disorders inhibited by SGLT2 with them, and processes for preparing them.

Practical and efficient method for amino acid derivatives containing β-quaternary center: application toward synthesis of hepatitis C virus NS3 serine protease inhibitors

A practical and efficient route toward synthesis of amino acid derivatives containing β-quaternary center has been developed using diastereoselective Strecker reaction. The method was employed for preparation of >100 g of β-methylcyclohexyl glycine deriva