826-86-8

Basic information

• Product Name: 2,3-Dihydro-2-methyl-4H-1-benzothiopyran-4-one
• Synonyms: 2,3-Dihydro-2-methyl-4H-1-benzothiopyran-4-one
• CAS NO: 826-86-8
• Molecular Formula: C₁₀H₁₀OS
• Molecular Weight: 0
• Mol File: 826-86-8.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2,3-Dihydro-2-methyl-4H-1-benzothiopyran-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydro-2-methyl-4H-1-benzothiopyran-4-one(826-86-8)
• EPA Substance Registry System: 2,3-Dihydro-2-methyl-4H-1-benzothiopyran-4-one(826-86-8)

Safety Data

• Hazardous Substances Data: 826-86-8(Hazardous Substances Data)

Usage

General Description

2,3-Dihydro-2-methyl-4H-1-benzothiopyran-4-one, also known as Benzothiopyranone, is a chemical compound with a molecular formula C11H10O2S. It is a cyclic organic compound that contains a benzene ring fused to a five-membered sulfur-containing ring. Benzothiopyranone has been identified as a potential candidate for various pharmaceutical applications, including its use as a photosensitizer in photodynamic therapy for cancer treatment. It is also being studied for its potential anti-inflammatory and antioxidant properties. Additionally, it has been investigated for its potential use as a building block in the synthesis of various organic compounds. Benzothiopyranone is a versatile chemical that continues to be of interest for its potential applications in the field of medicine and organic chemistry.

Upstream product

• 880-13-7 2-hydroxycarbonyl-1-methylethyl phenyl sulfide 
• 771-40-4 2-methyl-4H-thiochromen-4-one 
• 7664-93-9 sulfuric acid 
• 108-98-5 thiophenol 
• 110-89-4 piperidine 
• 107-93-7 (E)-but-2-enoic acid 
• 3724-65-0 2-butenoic acid 
• 491-39-4 thiochromen-4-one 
• 15681-48-8 dimethyllithium cuprate 
• 5219-65-8 acide phenylthio-3 propanoique 
• 3528-17-4 2,3-dihydro-4H-[1]benzothiopyran-4-one 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 77820-73-6 dimethyl 3-methyl-5-oxo-2,3,4,5-tetrahydro-1-benzothiepin-2,2-dicarboxylate 
• 77820-74-7 dimethyl (2-crotonoylphenyl)thiomalonate 
• 77820-71-4 2-methyl-4-oxothiochroman-1-io(bismethoxycarbonyl)methanide 
• 23086-34-2 2-methyl-4-oxothiochroman S-oxide 
• 78073-15-1 2-methyl-1-(p-tolylsulphonylimino)thiochroman-4-one 
• 78073-16-2 2-crotonoyl-N-(p-tolylsulphonyl)benzenesulphenamide 
• 16808-50-7 2-methyl-1-thiochroman-4-one 1,1-dioxide 
• 771-40-4 2-methyl-4H-thiochromen-4-one 
• 78073-22-0 3-methyl-2-p-tolylsulphonyl-2,3-dihydro-1,2-benzothiazepin-5(4H)-one 

Relevant articles and documents

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Hydrazone derivatives enhance antileishmanial activity of thiochroman-4-ones

Cutaneous leishmaniasis (CL) is a neglected tropical disease, which causes severe skin lesions. Due to the lack of effective vaccines, and toxicity or reduced effectiveness of available drugs in addition to complex and prolonged treatments, there is an urgent need to develop alternatives for the treatment for CL with different mechanisms of action. In our effort to search for new promising hits against Leishmania parasites we prepared 18 acyl hydrazone derivatives of thiochroman-4-ones. Compounds were evaluated for their in vitro antileishmanial activity against the intracellular amastigote form of Leishmania panamensis and cytotoxic activity against human monocytes (U-937 ATCC CRL-1593.2). Our results show that derivatization of the thiochroman-4-ones with acyl hydrazones significantly enhances the antileishmanial activity. Among the compounds tested semicarbazone and thiosemicarbazone derivatives of thioflavanone 19 and 20 displayed the highest antileishmanial activities, with EC50 values of 5.4 and 5.1 μM and low cytotoxicities (100.2 and 50.1 μM respectively), resulting in higher indexes of selectivity (IS).

COMPOUNDS FOR USE AS AN ANTI-BACTERIAL OR ANTI-FUNGAL AGENT AND AS A ZINC SENSOR

The present invention relates to a compound, which can be used as an anti-bacterial and/or an anti-fungal agent as well as a zinc sensor. Moreover, the present invention relates to a pharmaceutical composition comprising said compound and methods for treating bacterial or fungal infections in mammals.