827024-65-7Relevant articles and documents
Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs
Chen, Ying,Zhang, Qian,Zhang, Beina,Xia, Peng,Xia, Yi,Yang, Zheng-Yu,Kilgore, Nicole,Wild, Carl,Morris-Natschke, Susan L.,Lee, Kuo-Hsiung
, p. 6383 - 6387 (2004)
Two thia-DCK analogs (3a,b) were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes. Compound 3a showed potent anti-HIV activity with an EC50 value of 0.14 μM and a therapeutic index of 1110. However, the corresponding 6-tert-butyl-substituted compound (3b) showed no suppression. The bioassay results indicated that thia-DCK analogs merit attention as potential HIV-1 inhibitors.