82882-56-2

Basic information

• Product Name: Pyrimidine, 2-(1H-pyrazol-1-yl)- (9CI)
• Synonyms: Pyrimidine, 2-(1H-pyrazol-1-yl)- (9CI);2-(1H-pyrazol-1-yl)Pyrimidine
• CAS NO: 82882-56-2
• Molecular Formula: C₇H₆N₄
• Molecular Weight: 146.14934
• Product Categories: PYRIMIDINE
• Mol File: 82882-56-2.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrimidine, 2-(1H-pyrazol-1-yl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2-(1H-pyrazol-1-yl)- (9CI)(82882-56-2)
• EPA Substance Registry System: Pyrimidine, 2-(1H-pyrazol-1-yl)- (9CI)(82882-56-2)

Safety Data

• Hazardous Substances Data: 82882-56-2(Hazardous Substances Data)

Upstream product

• 288-13-1 NH-pyrazole 
• 1722-12-9 2-chloropyrimidine 
• 4595-60-2 2-bromopyrimidine 
• 79-04-9 chloroacetyl chloride 
• 557-01-7 2-hydroxypyrimidine 

Downstream Products

• 852807-28-4 3-[4-(3-chlorophenyl)piperazin-1-yl]-1-[1-(pyrimidin-2-yl)-1H-pyrazol-4-yl]propan-1-one 
• 438037-59-3 Pd(C₆F₅)2(pzpm) 
• 438037-63-9 Pd(C₆HF₄)2(pzpm) 
• 438037-61-7 Pt(C₆F₅)2(pzpm) 
• 857641-46-4 2-(4-bromo-1H-pyrazol-1-yl)pyrimidine 
• 1448310-20-0 1-(pyrimidin-2-yl)-1H-pyrazole-5-carboxylic acid 

Relevant articles and documents

Synthesis, characterization and dynamic behavior of (π-allyl)palladium complexes with polydentate nitrogen ligands, evidence of a dissociative mechanism

New examples of the fluxional behavior of (η3-allyl)palladium complexes are described. Variable-temperature experiments and line-shape analysis of two (η3-allyl)palladium complexes containing 2-(1H-pyrazol-1-yl)azine ligands were performed in order to determine the activation free energies, enthalpies and entropies of the process. A dissociative mechanism pointing to a selective Pd-N cleavage is proposed on the basis of these results and NOE experiments above and below the coalescence temperature. VCH Verlagsgesellschaft mbH, 1996.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues

The structural diversity and SAR in a series of imidazopyridazine inhibitors of Plasmodium falciparum calcium dependent protein kinase 1 (PfCDPK1) has been explored and extended. The opportunity to further improve key ADME parameters by means of lowering log D was identified, and this was achieved by replacement of a six-membered (hetero)aromatic linker with a pyrazole. A short SAR study has delivered key examples with useful in vitro activity and ADME profiles, good selectivity against a human kinase panel and improved levels of lipophilic ligand efficiency. These new analogues thus provide a credible additional route to further development of the series.