82964-04-3 Usage
Description
Tolrestat is a long-acting aldose reductase inhibitor, which is reportedly useful in the prophylaxis of diabetic neuropathy, retinopathy, and cataracts. It has been shown to decrease galactitol and sorbitol accumulation in various rat models, as well as reduce urinary total protein excretion in a rat model of diabetes induced by streptozotocin.
Used in Pharmaceutical Industry:
Tolrestat is used as an aldose reductase inhibitor for the prevention and treatment of diabetic complications such as neuropathy, retinopathy, and cataracts. Its ability to decrease the accumulation of galactitol and sorbitol in nerve tissues and lens, as well as reduce urinary total protein excretion, makes it a promising candidate for managing these conditions in diabetic patients.
Used in Ophthalmology:
Tolrestat is used as a prophylactic agent for cataract formation in patients with diabetes. Topical administration of Tolrestat has been shown to decrease levels of galactitol in the lens and inhibit cataract formation in rats fed a high-galactose diet, indicating its potential use in preventing cataract development in diabetic patients.
Note: The term "Alredase" mentioned in the provided materials does not seem to be related to Tolrestat. It might be a typo or an unrelated term.
Originator
American Home Products (USA)
Biochem/physiol Actions
Tolrestat is considered to be effective in treating the consequences of diabetes including neuropathy, nephropathy, retinopathy and esophageal motility and vibration perception. Tolrestat is also believed to have lesser or no toxic effects.
Check Digit Verification of cas no
The CAS Registry Mumber 82964-04-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,9,6 and 4 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 82964-04:
(7*8)+(6*2)+(5*9)+(4*6)+(3*4)+(2*0)+(1*4)=153
153 % 10 = 3
So 82964-04-3 is a valid CAS Registry Number.
InChI:InChI=1/C16H14F3NO3S/c1-20(8-13(21)22)15(24)11-5-3-4-10-9(11)6-7-12(23-2)14(10)16(17,18)19/h3-7H,8H2,1-2H3,(H,21,22)
82964-04-3Relevant articles and documents
USE OF SUBSTITUTED 2 PHENYLBENZIMIDAZOLES AS MEDICAMENTS
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, (2008/06/13)
The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R 4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula
