82989-27-3

Basic information

• Product Name: 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER
• Synonyms: 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER;Benzenepropanoic acid, 4-(trifluoroMethyl)-, ethyl ester
• CAS NO: 82989-27-3
• Molecular Formula: C₁₂H₁₃F₃O₂
• Molecular Weight: 246.23
• Mol File: 82989-27-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 260.238°C at 760 mmHg
• Flash Point: 80.914°C
• Appearance: /
• Density: 1.179g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.453
• CAS DataBase Reference: 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER(82989-27-3)
• EPA Substance Registry System: 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER(82989-27-3)

Safety Data

• Hazardous Substances Data: 82989-27-3(Hazardous Substances Data)

Usage

General Description

3-(4-trifluoromethyl-phenyl)-propionic acid ethyl ester is a chemical compound with the molecular formula C12H12F3O2. It is an ester derivative of 3-(4-trifluoromethyl-phenyl)-propionic acid, and is commonly used in the preparation of pharmaceuticals and agrochemicals. It is a white solid with a melting point of 60-63°C and is sparingly soluble in water but soluble in most organic solvents. 3-(4-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER is known for its anti-inflammatory and analgesic properties, making it a useful ingredient in many medication formulations. It is also used in the synthesis of various organic compounds and drug intermediates.

InChI:InChI=1/C12H13F3O2/c1-2-17-11(16)8-5-9-3-6-10(7-4-9)12(13,14)15/h3-4,6-7H,2,5,8H2,1H3

Upstream product

• 101466-85-7 ethyl 4-trifluoromethylcinnamate 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 98-56-6 4-chlorobenzotrifluoride 
• 140-88-5 ethyl acrylate 
• 16642-92-5 4-(trifluoromethyl)cinnamic acid 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 349-95-1 4-(trifluoromethyl)benzylic alcohol 
• 1071-46-1 hydrogen ethyl malonate 
• 539-74-2 Ethyl 3-bromopropionate 
• 819066-28-9 C₁₄H₁₇F₃O₂ 

Downstream Products

• 168285-22-1 2-Thioxo-5-(4-trifluoromethyl-benzyl)-2,3-dihydro-1H-pyrimidin-4-one 
• 603999-84-4 3-oxo-5-[4-(trifluoromethyl)phenyl]pentanenitrile 
• 166947-09-7 3-(4-trifluoromethylphenyl)propanal 
• 124426-67-1 3-[4-(trifluoromethyl)phenyl]propionamide 

Relevant articles and documents

METHOD FOR PRODUCING 3-ARYLPROPIONAMIDE COMPOUND AND 3-ARYLPROPIONIC ACID ESTER COMPOUND

The present invention provides a method for industrially producing: a pyrimidine compound having pest control efficacy; 2-[4-(trifluoromethyl)phenyl]ethylamine which is a production intermediate of the pyrimidine compound; a phenylethylamine compound usef

Photodriven Transfer Hydrogenation of Olefins

An improved practical method for the photodriven diimide reduction of olefins was investigated. This catalyst-free procedure proceeds at ambient temperature, utilizes air as oxidant and a lower hydrazine loading, and produces inert nitrogen gas as the sole byproduct. Several functional groups were tolerated, and in some cases, the reaction was chemoselective. Challenging substrates such as cinnamate ester derivatives and trans-stilbene were reduced in excellent yields. The small amount of UVA rays emitted from a household compact fluorescent light bulb was proposed to enable the cis/trans isomerization of the diimide and to promote the loss of hydrogen from the diimide.

Fluorous oxime palladacycle: A precatalyst for carbon-carbon coupling reactions in aqueous and organic medium

To facilitate precatalyst recovery and reuse, we have developed a fluorous, oxime-based palladacycle 1 and demonstrated that it is a very efficient and versatile precatalyst for a wide range of carbon-carbon bond formation reactions (Suzuki-Miyaura, Sonogashira, Stille, Heck, Glaser-type, and Kumada) in either aqueous or organic medium under microwave irradiation. Palladacycle 1 could be recovered through F-SPE in various coupling reactions with recovery ranging from 84 to 95% for the first cycle. Inductively coupled plasma optical emission spectrometry (ICP-OES) analyses of the Pd content in the crude product from each class of transformation indicated extremely low levels of leaching and the palladacycle could be reused four to five times without significant loss of activity.