83004-11-9

Basic information

• Product Name: 2-Pyridinemethanamine,6-bromo-N,N-dimethyl-
• Synonyms: (6-Bromopyridin-2-ylmethyl)dimethylamine
• CAS NO: 83004-11-9
• Molecular Formula: C₈H₁₁BrN₂
• Molecular Weight: 215.09
• Mol File: 83004-11-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyridinemethanamine,6-bromo-N,N-dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinemethanamine,6-bromo-N,N-dimethyl-(83004-11-9)
• EPA Substance Registry System: 2-Pyridinemethanamine,6-bromo-N,N-dimethyl-(83004-11-9)

Safety Data

• Hazardous Substances Data: 83004-11-9(Hazardous Substances Data)

Upstream product

• 83004-10-8 2-bromo-6-bromomethylpyridine 
• 124-40-3 dimethyl amine 
• 34160-40-2 6-bromo-2-pyridinecarbaldehyde 
• 506-59-2 N,N-dimethylammonium chloride 
• 5315-25-3 2-bromo-6-methylpyridine 

Relevant articles and documents

HPK1 ANTAGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Ester Hydrogenation Catalyzed by CNN-Pincer Complexes of Ruthenium

Ruthenium complexes supported by two new CNN-pincer ligands were synthesized. Both were tested as catalysts for the hydrogenation of esters under mild conditions (105 °C, 6 bar H2). A striking dependence on ligand structure was observed, as a dimethylamino-substituted ligand gave a nearly inactive catalyst, while a diethylamino-substituted variant gave up to 980 catalytic turnovers for the hydrogenation of benzyl benzoate. This system catalyzes the hydrogenation of various substrates including ethyl, benzyl, and hexyl esters, but is surprisingly unreactive toward methyl esters. Experiments demonstrate that base-catalyzed transesterification is rapid under the reaction conditions and that methyl esters are effectively hydrogenated when benzyl alcohol is added to the reaction mixture. The reverse reaction, dehydrogenation of primary alcohols to give esters, was tested as well; up to 920 catalytic turnovers were observed for the dehydrogenation of 1-hexanol to hexyl hexanoate.

7-(Aryl/heteroaryl-2-ylethynyl)-4-phenylamino-3-quinolinecarbonitriles as new Src kinase inhibitors: Addition of water solubilizing groups

New 4-phenylamino-3-quinolinecarbonitriles with a 7-ethynyl group substituted by a pyridine, phenyl or thiophene ring containing basic water solubilizing groups were prepared and evaluated as Src kinase inhibitors. Of these new analogs, potent activity wa