83228-40-4

Basic information

• Product Name: methyl 3-(2-methylanilino)propionate
• Synonyms: methyl 3-(2-methylanilino)propionate
• CAS NO: 83228-40-4
• Molecular Weight: 193.246
• Mol File: 83228-40-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: methyl 3-(2-methylanilino)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(2-methylanilino)propionate(83228-40-4)
• EPA Substance Registry System: methyl 3-(2-methylanilino)propionate(83228-40-4)

Safety Data

• Hazardous Substances Data: 83228-40-4(Hazardous Substances Data)

Usage

Description

Methyl 3-(2-methylanilino)propionate is an organic compound with a molecular formula C12H15NO2. It is a derivative of propionic acid and contains a methyl ester group, a 3-carbon chain, and a 2-methylanilino group. This chemical is commonly used in the synthesis of pharmaceuticals and dyes due to its unique structure and reactivity. It can also be used as a fragrance material in perfumes and personal care products. Methyl 3-(2-methylanilino)propionate is a versatile compound with various applications in the chemical and pharmaceutical industries.

Uses

Used in Pharmaceutical Industry:
Methyl 3-(2-methylanilino)propionate is used as an intermediate in the synthesis of pharmaceuticals for its unique structure and reactivity.
Used in Dye Industry:
Methyl 3-(2-methylanilino)propionate is used in the synthesis of dyes due to its unique structure and reactivity.
Used in Fragrance Industry:
Methyl 3-(2-methylanilino)propionate is used as a fragrance material in perfumes and personal care products for its unique scent and properties.

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 95-53-4 o-toluidine 

Downstream Products

• 1422186-22-8 1-tosyl-4,4,8-trimethyl-1,2,3,4-tetrahydroquinoline 
• 80-28-4 N-(2-methylphenyl)-p-toluenesulphonamide 
• 1422186-13-7 N-tosyl-4-(2-methylanilino)-2-methyl-2-butanol 

Relevant articles and documents

Lipase immobilization on hyroxypropyl methyl cellulose support and its applications for chemo-selective synthesis of β-amino ester compounds

The present study carried out the synthesis of β-amino ester compounds using lipase immobilized on hyroxypropyl methyl cellulose (HMC) support. Initially various lipases (biocatalysts) from different origin were immobilized and subsequently screened to obtain the robust biocatalyst. The lipase Pseudomonas fluorescence (PFL) immobilized on HMC was displayed highest lipase activity, protein content and retention of activity. The physical and biochemical characterization verified immobilization of lipase PFL on the HMC support. This immobilized biocatalyst HMC:PFL (3.5:1) was successfully applied for the practical biocatalytic applications to synthesize variety of β-amino esters. Various eight reaction parameters were optimized in details to achieve the maximum yield and chemo-selectively. The developed biocatalytic protocol was successfully applied to synthesize different industrially important β-amino esters compounds (21 substrates) with an excellent yield (>90%) and remarkable chemo selectivity (>94%). Interestingly, the immobilized HMC:PFL lipase showed 2.1–2.5 folds higher bio-catalytic activity and five times recyclability as compared to the free PFL. The plausible mechanism for lipase catalyzed synthesis of β-amino ester compounds was also proposed.

Tetrahydroquinolines by lewis acid-promoted friedel-crafts cyclizations

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Silicon tetrachloride catalyzed aza-michael addition of amines to conjugated alkenes under solvent-free conditions

The efficient and very simple conjugate addition of aromatic and aliphatic amines to α,β-unsaturated carbonyl compounds under solvent-free conditions in the presence of catalytic amount of silicon tetrachloride is reported. The reaction of aryl and alkyl amines with different Michael acceptors gave the corresponding Michael adducts with simple catalyst and good to excellent yields. Georg Thieme Verlag Stuttgart New York.