83245-15-2

Basic information

• Product Name: SERINE, L-[3-3H]
• Synonyms: L-SERINE, [3H]-;L-SERINE-[3H(G)];L-SERINE, [G-3 H];SERINE, L-[3-3H];SERINE, L-, [3H(G)];L-serine-(3H(G)) mol. wt. 105.1
• CAS NO: 83245-15-2
• Molecular Formula: C3H5NO3T2
• Molecular Weight: 109.11
• Mol File: 83245-15-2.mol
• Article Data: 358

Chemical Properties

• Appearance: /aqueous ethanol solution
• Storage Temp.: 2-8°C
• CAS DataBase Reference: SERINE, L-[3-3H](CAS DataBase Reference)
• NIST Chemistry Reference: SERINE, L-[3-3H](83245-15-2)
• EPA Substance Registry System: SERINE, L-[3-3H](83245-15-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37
• RIDADR: UN 2910 7
• WGK Germany: 3
• Hazardous Substances Data: 83245-15-2(Hazardous Substances Data)

Usage

General Description

"SERINE, L-[3-3H]" is a radioactive form of the amino acid serine, labeled with the radioactive isotope tritium. Serine is a non-essential amino acid that is involved in the biosynthesis of proteins, phospholipids, and nucleotides. The radioactive form of serine, L-[3-3H], can be used in biochemical and cell biology research to trace the metabolism and synthesis of serine within cells. It is commonly used as a radiotracer in metabolic labeling experiments to study the turnover and utilization of serine in various biological processes. Additionally, L-[3-3H] serine may also be utilized in radioimmunoassays and other analytical techniques for the detection and quantification of serine in biological samples.

Upstream product

• 107-97-1 sarcosine 
• 56-45-1 L-serin 
• 3981-36-0 3-chloro-DL-alanine 
• 19794-53-7 3-methoxy-2-aminopropionic acid 
• 22056-82-2 ethoxyacetaldehyde 
• 6267-40-9 acetylamino-hydroxymethyl-malonic acid diethyl ester 
• 1186-47-6 1,1-dihydroxyacetone 
• 4783-22-6 N-benzoyl-serine ethyl ester 
• 5445-44-3 O-benzylserine 
• 872790-82-4 acetylamino-hydroxymethyl-malonic acid 
• 64-19-7 acetic acid 
• 141-46-8 Glycolaldehyde 
• 50-00-0 formaldehyd 
• 56-40-6 glycine 

Downstream Products

• 2788-84-3 (S)-serine methyl ester 
• 68762-64-1 N-(α-acetylamino-cinnamoyl)-serine 
• 99945-10-5 N-[(2,4-dichloro-phenoxy)-acetyl]-D-serine 
• 1738-72-3 L-serine benzyl ester 
• 50648-97-0 N-[(2,4-dichloro-phenoxy)-acetyl]-L-serine 
• 99856-41-4 N-benzylsulfanylcarbonyl-DL-serine 
• 100100-92-3 N-[(2,4,5-trichloro-phenoxy)-acetyl]-DL-serine 
• 13588-99-3 H-Tyr-Ser-OH 
• 13588-99-3 N-L-tyrosyl-D-serine 
• 91841-16-6 N-(N,N-phthaloyl-glycyl)-DL-serine 
• 73912-83-1 N-(1-benzyloxycarbonyl-L-prolyl)-L-serine 
• 97-14-3 N-acetyl-serine 
• 179806-81-6 N-(2,4-dinitrophenyl)-D-serine 
• 10547-30-5 N-(2,4-dinitrophenyl)-D,L-serine 

Relevant articles and documents

Ruckerbactin Produced by Yersinia ruckeri YRB Is a Diastereomer of the Siderophore Trivanchrobactin Produced by Vibrio campbellii DS40M4

The Gram-negative bacterium Yersinia ruckeri is the causative agent for enteric red mouth disease in salmonids. The genome of Y. ruckeri YRB contains a biosynthetic gene cluster encoding the biosynthesis of catechol siderophores that are diastereomeric with the known vanchrobactin class of siderophores, (DHBDArgLSer)(1–3). Ruckerbactin (1), produced by Y. ruckeri YRB, was found to be the linear tris-l-serine ester composed of l-arginine and 2,3-dihydroxybenzoic acid, (DHBLArgLSer)3. The biscatechol, (DHBLArgLSer)2 (2), and monocatechol, DHBLArgLSer (3), compounds were also isolated and characterized. The macrolactone of ruckerbactin was not detected. The presence of LArg in ruckerbactin makes it the diastereomer of trivanchrobactin with DArg. The electronic circular dichroism spectra of Fe(III)–ruckerbactin and Fe(III)–trivanchrobactin reveal the opposite enantiomeric configurations at the Fe(III) sites. Fe(III)–ruckerbactin adopts the Δ configuration, and Fe(III)–trivanchrobactin adopts the Λ configuration. Y. ruckeri YRB was also found to produce the antimicrobial agent holomycin (4).

Direct monitoring of biocatalytic deacetylation of amino acid substrates by1H NMR reveals fine details of substrate specificity

Amino acids are key synthetic building blocks that can be prepared in an enantiopure form by biocatalytic methods. We show that thel-selective ornithine deacetylase ArgE catalyses hydrolysis of a wide-range ofN-acyl-amino acid substrates. This activity was revealed by1H NMR spectroscopy that monitored the appearance of the well resolved signal of the acetate product. Furthermore, the assay was used to probe the subtle structural selectivity of the biocatalyst using a substrate that could adopt different rotameric conformations.

Leveraging Peptaibol Biosynthetic Promiscuity for Next-Generation Antiplasmodial Therapeutics

Malaria remains a worldwide threat, afflicting over 200 million people each year. The emergence of drug resistance against existing therapeutics threatens to destabilize global efforts aimed at controlling Plasmodium spp. parasites, which is expected to leave vast portions of humanity unprotected against the disease. To address this need, systematic testing of a fungal natural product extract library assembled through the University of Oklahoma Citizen Science Soil Collection Program has generated an initial set of bioactive extracts that exhibit potent antiplasmodial activity (EC50 25 μM, selectivity index > 250). The unique chemodiversity afforded by these fungal isolates serves to unlock new opportunities for translating peptaibols into a bioactive scaffold worthy of further development.