83393-60-6

Basic information

• Product Name: 3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one
• Synonyms: 3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one;3-[2-(Furan-2-yl)-2-oxoethyl]-3-hydroxy-2,3-dihydro-1H-indol-2-one;3-(2-Furan-2-yl-2-oxo-ethyl)-3-hydroxy-1,3-dihydro-indol-2-one
• CAS NO: 83393-60-6
• Molecular Formula: C14H11NO4
• Molecular Weight: 257.24144
• Mol File: 83393-60-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 189-190 °C(Solv: ethanol (64-17-5))
• Boiling Point: 525.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.381±0.06 g/cm3(Predicted)
• PKA: 11.42±0.20(Predicted)
• CAS DataBase Reference: 3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one(83393-60-6)
• EPA Substance Registry System: 3-[2-(furan-2-yl)-2-oxoethyl]-3-hydroxy-1H-indol-2-one(83393-60-6)

Safety Data

• Hazardous Substances Data: 83393-60-6(Hazardous Substances Data)

Upstream product

• 1192-62-7 1-(2-furyl)-1-ethanone 
• 91-56-5 indole-2,3-dione 
• 59-48-3 2-oxoindole 

Downstream Products

• 20146-25-2 2-(furan-2-yl)quinoline-4-carboxylic acid 

Relevant articles and documents

"on Water" Catalytic Aldol Reaction between Isatins and Acetophenones: Interfacial Hydrogen Bonding and Enamine Mechanism

"On water" catalytic aldol reaction catalyzed by polyetheramine (D230) has been developed for easy access to 3-substituted 3-hydroxyindolin-2-ones through the reaction between various substituted isatins and acetophenones/cyclic ketones in high yields under room temperature. Systematic mechanism investigation uncovers the secret for the on water catalytic aldol reaction: comparison of the heterogeneous and homogeneous reaction circumstances with yields of 95 and 20%, respectively, indicates the on-water reaction dominating; interfacial hydrogen bonding between isatin with H2O is tested based on the downfield shift of the C2 and C3's 13C NMR signals when water was added to the CDCl3 solution of isatin; Lewis base polyetheramine D230 catalyzes the aldol reaction via the enamine mechanism verified by in situ NMR and ESI-MS analysis.

Catalyst-free aldol condensation of ketones and isatins under mild reaction conditions in DMF with molecular sieves 4 A as additive

In the presence of molecular sieve (MS) 4 A in DMF, a catalyst-free aldol condensation of a variety of aromatic and aliphatic ketones with isatins under mild reaction conditions has been developed. This approach may provide access to a wide range of 3-sub

Potential anticonvulsants. V. The condensation of isatins with C-acetyl heterocyclic compounds

A number of C-acetyl heterocyclic compounds were condensed with isatin and substituted isatins to give a series of 3-hydroxy-3-substituted oxindoles. The products from 2-acetylfuran and isatin, 2-acetylthiophene and isatin, and 2-acetylpyridine and 1-meth