83435-67-0 Usage
Description
Delapril Hydrochloride, also known as Delapril HCL, is a pharmaceutical compound that functions as an angiotensin-converting enzyme (ACE) inhibitor. It is a prodrug, which means it is converted into its active form, the diacid metabolite, after oral administration. Delapril HCL is particularly effective in the treatment of essential hypertension, as it significantly reduces systolic blood pressure and ACE activity without impacting endogenous creatinine clearance.
Uses
Used in Pharmaceutical Industry:
Delapril HCL is used as an antihypertensive drug for the management of essential hypertension. It is particularly effective in reducing systolic blood pressure and ACE activity, which are key factors in controlling high blood pressure.
Delapril HCL is used as a pharmaceutical compound for the treatment of essential hypertension in some European and Asian countries. It is not approved for use in America, but its effectiveness in managing blood pressure makes it a valuable asset in regions where it is available.
Originator
Takeda (Japan)
Check Digit Verification of cas no
The CAS Registry Mumber 83435-67-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,4,3 and 5 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 83435-67:
(7*8)+(6*3)+(5*4)+(4*3)+(3*5)+(2*6)+(1*7)=140
140 % 10 = 0
So 83435-67-0 is a valid CAS Registry Number.
InChI:InChI=1/C26H32N2O5.ClH/c1-3-33-26(32)23(14-13-19-9-5-4-6-10-19)27-18(2)25(31)28(17-24(29)30)22-15-20-11-7-8-12-21(20)16-22;/h4-12,18,22-23,27H,3,13-17H2,1-2H3,(H,29,30);1H/t18-,23-;/m0./s1
83435-67-0Relevant articles and documents
PROCESS FOR THE PREPARATION OF AMIDES OF N-[1-(S)-(ETHOXYCARBONYL)-3-PHENYLPROPYL]-L-ALANINE
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, (2015/01/07)
A process for the production of amides of N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine is described. The process can be used for the production of key intermediates and finally the ACE inhibitors such as Ramipril, Enalapril, Quinapril, Trandolapril, Delapril and Moexipril starting from N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine by the reaction with the appropriate amines.
Method for producing indan derivatives
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, (2008/06/13)
A method for producing an indan derivative represented by the formula: STR1 by condensing an N-(α-alkoxycarbonylaralkyl)-α-amino acid with an N-(indan-2-yl)glycine alkyl or aralkyl ester in the presence of a diphenyl phosphorochloridate, and a method for