835-11-0

Basic information

• Product Name: 2,2'-DIHYDROXYBENZOPHENONE
• Synonyms: AURORA KA-485;2,2'-Dihydroxybenzophenone 98%;Benzophenone, 2,2'-dihydroxy-;Bis-(2-hydroxy-phenyl)-methanone;Bis(2-hydroxyphenyl)methanone;Methanone, bis(2-hydroxyphenyl)-;Methanone,bis(2-hydroxyphenyl)-;2,2'-DIHYDROXYBENZOPHENONE
• CAS NO: 835-11-0
• Molecular Formula: C₁₃H₁₀O₃
• Molecular Weight: 214.22
• EINECS: 212-639-4
• Product Categories: Benzophenones (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research;C13 to C14;Carbonyl Compounds;Ketones;Building Blocks;C13 to C14;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 835-11-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 61-62.5 °C(lit.)
• Boiling Point: 333°C (estimate)
• Flash Point: 166.8 °C
• Appearance: /
• Density: 1.1956 (rough estimate)
• Refractive Index: 1.5090 (estimate)
• Solubility: almost transparency in Methanol
• PKA: 7.32±0.30(Predicted)
• CAS DataBase Reference: 2,2'-DIHYDROXYBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-DIHYDROXYBENZOPHENONE(835-11-0)
• EPA Substance Registry System: 2,2'-DIHYDROXYBENZOPHENONE(835-11-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 835-11-0(Hazardous Substances Data)

Usage

Preparation

Preparation by diazotization of 4,4′-diamino-2,2′- di-hydroxybenzophenone in diluted hydrochloric acid, followed by treatment with 50% phosphorous acid at 0° for 1 h, then at r.t. for 24 h (34%).

Upstream product

• 90-47-1 xanth-9-one 
• 134-55-4 phenyl 2-acetoxybenzoate 
• 201230-82-2 carbon monoxide 
• 90-03-9 (2-hydroxyphenyl)mercury chloride 
• 7446-70-0 aluminium trichloride 
• 98-95-3 nitrobenzene 
• 609-65-4 o-chlorobenzoyl chloride 
• 119-61-9 benzophenone 
• 89466-08-0 2-hydroxyphenyl boronic acid 
• 13102-33-5 2,2'-dimethoxybenzophenone 
• 578-57-4 2-bromoanisole 
• 77464-21-2 2-methoxy-α-(2-methoxyphenyl)benzenemethanol 
• 135-02-4 ortho-anisaldehyde 
• 90-02-8 salicylaldehyde 

Downstream Products

• 2467-02-9 Bis(2-hydroxyphenyl)methane 
• 39265-04-8 2,2'-(2-morpholin-4-yl-ethyliminomethanediyl)-bis-phenol 
• 17087-18-2 DL-N--β-phenyl-alanin 
• 39265-09-3 N-(3-Dimethylaminopropyl)-2,2'-dihydroxy-diphenylketoimin 
• 39265-11-7 N-(4-Dimethylaminobutyl)-2,2'-dihydroxy-diphenylketoimin 
• 17087-14-8 DL-N--leucin 
• 57443-93-3 (Z)-2-Amino-3-{[bis-(2-hydroxy-phenyl)-methylene]-amino}-but-2-enedinitrile 
• 39265-07-1 N-(1-methyl-2-dimethylaminoethyl)-2,2'-dihydroxy-diphenylketoimin 
• 91955-15-6 2,2'-Dihydroxy-benzophenon-hydrazon 
• 95950-25-7 2,2',2'',2'''-Tetrahydroxy-benzophenon-azin 
• 74697-53-3 2,2'-bis(benzyloxy)benzophenone 
• 97990-55-1 2,2'-Dihydroxybenzophenon-dimethylhydrazon 
• 117139-08-9 3-Chloro-4-(2-hydroxy-phenyl)-chromen-2-one 
• 117767-21-2 NSC₁₀₆₀₈₀ 

Relevant articles and documents

Selective Oxidation of Alkylarenes to the Aromatic Ketones or Benzaldehydes with Water

Here a palladium-catalyzed oxidation method for converting alkylarenes into the aromatic ketones or benzaldehydes with water as the only oxygen donor is reported. This C-H bond oxidation functionalization does not require other oxidants and hydrogen accep

Rhodium-Catalyzed Directing-Group-Assisted Aldehydic C–H Arylations with Aryl Halides

A rhodium-catalyzed general protocol for the directing-group-assisted arylation of aromatic aldehydic C–H bonds was developed. This method involves either hydroxy- or amino-group-directed aldehyde C–H arylation with various aryl halides. A broad synthetic scope for the preparation of 2-hydroxybenzophenones was established with electronically variant salicylaldehydes and aryl halides with chemo- and regioselective possibilities. The developed protocol was also applied in the synthesis of medicinally important 3-salicyloylpyridines in high yields.

Pd/Cu-cocatalyzed aerobic oxidative carbonylative homocoupling of arylboronic acids and CO: A highly selective approach to diaryl ketones

A highly selective Pd/Cu-cocatalyzed aerobic oxidative carbonylative homocoupling of arylboronic acids has been developed. This method employs a simple catalytic system, readily available boronic acids as the substrates, molecular oxygen as the oxidant, and 1 atm of CO/O2, which makes this method practical for further applications.