835-40-5 Usage
Description
3-(2-METHYL-2-NITROPROPYL)INDOLE is an organic compound that serves as an intermediate in the synthesis of Bucindolol (B689430), a high-affinity, competitive beta blocker. 3-(2-METHYL-2-NITROPROPYL)INDOLE plays a crucial role in the development of pharmaceuticals for the treatment of various cardiovascular conditions.
Uses
Used in Pharmaceutical Industry:
3-(2-METHYL-2-NITROPROPYL)INDOLE is used as a key intermediate in the synthesis of Bucindolol for its high-affinity, competitive beta-blocking properties. This makes it an essential component in the development of medications aimed at treating congestive heart failure and hypertension.
In the synthesis of Bucindolol, 3-(2-METHYL-2-NITROPROPYL)INDOLE contributes to the creation of a medication that effectively manages heart rate and blood pressure, providing relief and improved cardiovascular health for patients suffering from congestive heart failure and hypertension.
Check Digit Verification of cas no
The CAS Registry Mumber 835-40-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,3 and 5 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 835-40:
(5*8)+(4*3)+(3*5)+(2*4)+(1*0)=75
75 % 10 = 5
So 835-40-5 is a valid CAS Registry Number.
InChI:InChI=1/C12H14N2O2/c1-12(2,14(15)16)7-9-8-13-11-6-4-3-5-10(9)11/h3-6,8,13H,7H2,1-2H3
835-40-5Relevant articles and documents
Catalytic and Enantioselective Control of the C–N Stereogenic Axis via the Pictet–Spengler Reaction
Kim, Ahreum,Kim, Aram,Park, Sunjung,Kim, Sangji,Jo, Hongil,Ok, Kang Min,Lee, Sang Kook,Song, Jayoung,Kwon, Yongseok
supporting information, p. 12279 - 12283 (2021/05/03)
An unprecedented example of a chiral phosphoric acid-catalyzed atroposelective Pictet–Spengler reaction of N-arylindoles is reported. Highly enantioenriched N-aryl-tetrahydro-β-carbolines with C?N bond axial chirality are obtained via dynamic kinetic reso
Selective mono-alkylation of carbon nucleophiles with gramine
Somei, Masanori,Karasawa, Yoshio,Kaneko, Chikara
, p. 941 - 949 (2007/10/02)
Mono-alkylation method of carbon nucleophiles, especially for nitroalkanes, with gramine derivatives is reported