83520-63-2Relevant articles and documents
Aryloxybenzylidene ruthenium chelates: Synthesis, structure and catalytic activity in olefin metathesis
Z.ak, Patrycja,Rogalski, Szymon,Kubicki, Maciej,Przybylski, Piotr,Pietraszuk, Cezary
, p. 1131 - 1136 (2014)
New aryloxybenzylidene ruthenium chelates behave like a promising latent catalyst of olefin metathesis. The catalysts are characterised by substantial stability and catalytic inactivity in their dormant forms and a dramatic increase in activity after addi
3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors
Pustenko, Aleksandrs,Stepanovs, Dmitrijs,?alubovskis, Raivis,Vullo, Daniela,Kazaks, Andris,Leitans, Janis,Tars, Kaspars,Supuran, Claudiu T.
, p. 767 - 775 (2017/06/07)
A new chemotype with carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action has been discovered, the homo-sulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) which have been designed considering the (sulfo)coumarins as lead molecules. An original synthetic strategy of a panel of such derivatives led to compounds with a unique inhibitory profile and very high selectivity for the inhibition of the tumour associated (CA IX/XII) over the cytosolic (CA I/II) isoforms. Although the CA inhibition mechanism with these new compounds is unknown for the moment, we hypothesize that it may be similar to that of the sulfocoumarins, i.e. hydrolysis to the corresponding sulfonic acids which thereafter anchor to the zinc-coordinated water molecule within the enzyme active site.
Aryloxybenzylidene ruthenium chelates: Synthesis, structure and catalytic activity in olefin metathesis
Zak, Patrycja,Rogalski, Szymon,Kubicki, Maciej,Przybylski, Piotr,Pietraszuk, Cezary
supporting information, p. 1131 - 1136 (2015/04/27)
New aryloxybenzylidene ruthenium chelates behave like a promising latent catalyst of olefin metathesis. The catalysts are characterised by substantial stability and catalytic inactivity in their dormant forms and a dramatic increase in activity after addi